Physiological characterization of xylose metabolism in Aspergillus niger under oxygen-limited conditions.

Physiological characterization of xylose metabolism in Aspergillus niger under oxygen-limited conditions. Research Abstract Details 

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Physiological characterization of xylose metabolism in Aspergillus niger under oxygen-limited conditions. Abstract Text:

S Meijer,G Panagiotou,L Olsson,J Nielsen,S Meijer,G Panagiotou,L Olsson,J Nielsen,

The physiology of Aspergillus niger was studied under different aeration conditions. Five different aeration rates were investigated in batch cultivations of A. niger grown on xylose. Biomass, intra- and extra-cellular metabolites profiles were determined and ten different enzyme activities in the central carbon metabolism were assessed. The focus was on organic acid production with a special interest in succinate production. The fermentations revealed that oxygen limitation significantly changes the physiology of the micro-organism. Changes in extra cellular metabolite profiles were observed, that is, there was a drastic increase in polyol production (erythritol, xylitol, glycerol, arabitol, and mannitol) and to a lesser extent in the production of reduced acids (malate and succinate). The intracellular metabolite profiles indicated changes in fluxes, since several primary metabolites, like the intermediates of the TCA cycle accumulated during oxygen limitation (on average three fold increase). Also the enzyme activities showed changes between the exponential growth phase and the oxygen limitation phase. In general, the oxygen availability has a significant impact on the physiology of this fungus causing dramatic alterations in the central carbon metabolism that should be taken into account in the design of A. niger as a succinate cell factory. Biotechnol. Bioeng. 2007;98; 462-472. (c) 2007 Wiley Periodicals, Inc.

Physiological characterization of xylose metabolism in Aspergillus niger under oxygen-limited conditions. Publishing Authors By Initials

S Meijer,G Panagiotou,L Olsson,J Nielsen,S Meijer,G Panagiotou,L Olsson,J Nielsen,

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Physiological characterization of xylose metabolism in Aspergillus niger under oxygen-limited conditions. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biotechnology and bioengineering

VOLUME: 98

Page Numbers: 462-75

Journal Abbreviation: Biotechnol. Bioeng.

ISSN: 0006-3592

DAY: 1

MONTH: Oct

YEAR: 2007

Physiological characterization of xylose metabolism in Aspergillus niger under oxygen-limited conditions. Information

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LANGUAGE: eng

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AFFILIATION: Biocentrum-DTU, Center for Microbial Biotechnology, building, 223, Søltofts Plads, Technical University of Denmark, 2800 Kgs, Lyngby, Denmark.

Country: United States

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MEDLINETA: Biotechnol Bioeng

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