Physiological and pharmacokinetic roles of H+/organic cation antiporters (MATE/SLC47A).

Physiological and pharmacokinetic roles of H+/organic cation antiporters (MATE/SLC47A). Research Abstract Details 

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Physiological and pharmacokinetic roles of H+/organic cation antiporters (MATE/SLC47A). Abstract Text:

Vectorial secretion of cationic compounds across tubular epithelial cells is an important function of the kidney. This uni-directed transport is mediated by two cooperative functions, which are membrane potential-dependent organic cation transporters at the basolateral membranes and H+/organic cation antiporters at the brush-border membranes. More than 10 years ago, the basolateral organic cation transporters (OCT1-3/SLC22A1-3) were isolated, and molecular understandings for the basolateral entry of cationic drugs have been greatly advanced. However, the molecular nature of H+/organic cation antiport systems remains unclear. Recently, mammalian orthologues of the multidrug and toxin extrusion (MATE) family of bacteria have been isolated and clarified to function as H+/organic cation antiporters. In this commentary, the molecular characteristics and pharmacokinetic roles of mammalian MATEs are critically overviewed focusing on the renal secretion of cationic drugs.

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Physiological and pharmacokinetic roles of H+/organic cation antiporters (MATE/SLC47A). Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biochemical pharmacology

VOLUME: 75

Page Numbers: 1689-96

Journal Abbreviation: Biochem. Pharmacol.

ISSN: 0006-2952

DAY: 27

MONTH: 12

YEAR: 2007

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LANGUAGE: eng

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Grant and Affiliation Information for Physiological and pharmacokinetic roles of H+/organic cation antiporters (MATE/SLC47A).

AFFILIATION: Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan.

Country: England

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MEDLINETA: Biochem Pharmacol

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