Physicochemical basis of the universal genetic codes--quantitative analysis.

Physicochemical basis of the universal genetic codes--quantitative analysis. Research Abstract Details 

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Physicochemical basis of the universal genetic codes--quantitative analysis. Abstract Text:

Quantitative mathematic models have been developed to correlate the fragment hydrophobicity contribution constants (faa) of 20 amino acids with the physicochemical properties (mu, Hb, and square root of MW) of the four bases (U, A, C, G) of the codons, or those of the anticodons. Using the general equation faa = a mu 1 + b mu 2 + c mu 3 + d square root of MW1 + e square root of MW2 + f square root of MW3 + g Hb1 + h Hb2 + i Hb3 + j, where 1, 2, 3 refer to the first, the second and the third base respectively, correlation coefficient of about 0.82 can be obtained for all 20 amino acids coded by 61 different triplet codes. These correlations are statistically highly significant, even though they do not take into account the involvement of various factors and peptidyl transferases. Furthermore, the reasons for the three stop codons are revealed. The graphic presentation of the codons and the amino acids coded separates the acidic and the basic, the aromatic and the heterocyclic amino acids into different quadrants of an octagon. This is in agreement with the ancient Chinese Ying-Yang theory embedded in the classical I-Ching.

Physicochemical basis of the universal genetic codes--quantitative analysis. Publishing Authors By Initials

For similar natural sciences: mathematics research abstracts see: natural sciences: mathematics research

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Physicochemical basis of the universal genetic codes--quantitative analysis. Journal Published:

PUBLICATION TYPE: Review

Journal: Progress in drug research. Fortschritte der Arznei

VOLUME: 48

Page Numbers: 9-25

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ISSN: 0071-786X

DAY: 25

MONTH: 02

YEAR: 1997

Physicochemical basis of the universal genetic codes--quantitative analysis. Information

Number of References: 31

LANGUAGE: eng

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KEYWORDS: Mathematics

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Chemical & Substance for Abstract: Physicochemical basis of the universal genetic codes--quantitative analysis. Information

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Grant and Affiliation Information for Physicochemical basis of the universal genetic codes--quantitative analysis.

AFFILIATION: Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles 90033, USA.

Country: SWITZERLAND

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MEDLINETA: Prog Drug Res

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