Physical exercise-associated gene expression signatures in peripheral blood.

Physical exercise-associated gene expression signatures in peripheral blood. Research Abstract Details 

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Physical exercise-associated gene expression signatures in peripheral blood. Abstract Text:

Tomoko Kawai,Kyoko Morita,Kiyoshi Masuda,Kensei Nishida,Atsuo Sekiyama,Shigetada Teshima-Kondo,Yutaka Nakaya,Masayuki Ohta,Toshiro Saito,Kazuhito Rokutan,Tomoko Kawai,Kyoko Morita,Kiyoshi Masuda,Kensei Nishida,Atsuo Sekiyama,Shigetada Teshima-Kondo,Yutaka Nakaya,Masayuki Ohta,Toshiro Saito,Kazuhito Rokutan,

OBJECTIVE: To assess response to physical stress, gene expression profiles in peripheral blood cells were analyzed using an original microarray carrying 1467 stress-responsive complementary DNA probes. DESIGN: Gene expression was analyzed at 4, 24, and 48 hours after exercising on a cycle ergometer at 60% VO2 max for 1 hour (aerobic exercise) or until exhausted (exhaustive exercise). SETTING: Institute of Health Biosciences, University of Tokushima Graduate School. PARTICIPANTS: Twelve healthy male students of the postgraduate or undergraduate school. INTERVENTIONS: The volunteers performed the aerobic or exhaustive exercise on a cycle ergometer. MAIN OUTCOME MEASUREMENTS: Detection of aerobic exercise-responsive or exhaustive exercise-responsive genes in peripheral blood cells. RESULTS: Aerobic and exhaustive exercise transiently changed the expression of 21 and 16 genes, respectively, with the peak at 4 hours. Only 2 genes significantly responded to both types of exercise. Exhaustive but not aerobic exercise produced a secondary response with significantly altered expression of 14 genes at 24 hours. Five of those genes encode receptors for neurotransmitters (HTR1A, CHRNB2, GABRB3, GABRG3, and LOC51289). CONCLUSIONS: The behavior of the individual genes shown here may be informative to objectively assess acute physical stress and exhaustion-associated responses.

Physical exercise-associated gene expression signatures in peripheral blood. Publishing Authors By Initials

T Kawai,K Morita,K Masuda,K Nishida,A Sekiyama,S Teshima-Kondo,Y Nakaya,M Ohta,T Saito,K Rokutan,T Kawai,K Morita,K Masuda,K Nishida,A Sekiyama,S Teshima-Kondo,Y Nakaya,M Ohta,T Saito,K Rokutan,

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Physical exercise-associated gene expression signatures in peripheral blood. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Clinical journal of sport medicine : official jour

VOLUME: 17

Page Numbers: 375-83

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ISSN: 1050-642X

DAY: 17

MONTH: Sep

YEAR: 2007

Physical exercise-associated gene expression signatures in peripheral blood. Information

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LANGUAGE: eng

NlmUniqueID: 9103300

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AFFILIATION: Department of Stress Science, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.

Country: United States

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MEDLINETA: Clin J Sport Med

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