Physical activity and inactivity in relation to sex hormone, prolactin, and insulin-like growth factor concentrations in premenopausal women - exercise and premenopausal hormones.

Physical activity and inactivity in relation to sex hormone, prolactin, and insulin-like growth factor concentrations in premenopausal women - exercise and premenopausal hormones. Research Abstract Details 

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Physical activity and inactivity in relation to sex hormone, prolactin, and insulin-like growth factor concentrations in premenopausal women - exercise and premenopausal hormones. Abstract Text:

Shelley S Tworoger,Stacey A Missmer,A Heather Eliassen,Robert L Barbieri,Mitch Dowsett,Susan E Hankinson,

An association between physical activity and premenopausal breast cancer risk may be due, in part, to relationships with sex hormones or growth factors. Therefore, we assessed whether MET-h/week of total physical activity (moderate-to-vigorous intensity), walking, or vigorous physical activity, and h/week of standing or sitting were associated with plasma concentrations of several hormones. We examined levels of estrogens, androgens, progesterone, prolactin, sex hormone binding globulin (SHBG), insulin-like growth factor-1 (IGF-1), IGF binding protein-3, and growth hormone (GH) in 565 premenopausal women, ages 33-52 years, from the Nurses' Health Study II (NHSII). About 87% of women had both timed follicular and luteal samples; other women had one untimed sample. In general we observed few associations between sex hormone or IGF levels and measures of physical activity or inactivity. However, free testosterone was modestly inversely associated with total physical activity (p-trend = 0.02). Luteal estradiol, free estradiol, and estrone also were inversely associated with total physical activity (p-trend = 0.10, 0.04, 0.01, respectively); however, the trend was substantially attenuated when excluding women with anovulatory cycles or irregular cycles. These cross-sectional results suggest that physical activity and inactivity have limited associations with premenopausal sex hormone and growth factor levels, except possibly luteal estrogens.

Physical activity and inactivity in relation to sex hormone, prolactin, and insulin-like growth factor concentrations in premenopausal women - exercise and premenopausal hormones. Publishing Authors By Initials

SS Tworoger,SA Missmer,AH Eliassen,RL Barbieri,M Dowsett,SE Hankinson,

For similar proteins: blood proteins: serum globulins: beta-globulins: sex hormone-binding globulin research abstracts see: proteins: blood proteins: serum globulins: beta-globulins: sex hormone-binding globulin research

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Physical activity and inactivity in relation to sex hormone, prolactin, and insulin-like growth factor concentrations in premenopausal women - exercise and premenopausal hormones. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Cancer causes & control : CCC

VOLUME: 18

Page Numbers: 743-52

Journal Abbreviation: Cancer Causes Control

ISSN: 0957-5243

DAY: 5

MONTH: 06

YEAR: 2007

Physical activity and inactivity in relation to sex hormone, prolactin, and insulin-like growth factor concentrations in premenopausal women - exercise and premenopausal hormones. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9100846

Physical activity and inactivity in relation to sex hormone, prolactin, and insulin-like growth factor concentrations in premenopausal women - exercise and premenopausal hormones. Keywords Mesh Terms:

KEYWORDS: Sex Hormone-Binding Globulin

MESH TERMS: metabolism

Chemical & Substance for Abstract: Physical activity and inactivity in relation to sex hormone, prolactin, and insulin-like growth factor concentrations in premenopausal women - exercise and premenopausal hormones. Information

Substance Name: Prolactin

Registry Number: 9002-62-4

Grant and Affiliation Information for Physical activity and inactivity in relation to sex hormone, prolactin, and insulin-like growth factor concentrations in premenopausal women - exercise and premenopausal hormones.

AFFILIATION: Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Ave., 3rd Floor, Boston, MA 02115, USA. nhsst@channing.harvard.edu

Country: Netherlands

AGENCY: United States NCI

GRANT: R25CA 098566-2

ACRONYM: CA

MEDLINETA: Cancer Causes Control

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