Photophysical, electrochemical characteristics and cross-linking of STAT-3 protein by an efficient bifunctional agent for fluorescence image-guided photodynamic therapy.

Photophysical, electrochemical characteristics and cross-linking of STAT-3 protein by an efficient bifunctional agent for fluorescence image-guided photodynamic therapy. Research Abstract Details 

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Photophysical, electrochemical characteristics and cross-linking of STAT-3 protein by an efficient bifunctional agent for fluorescence image-guided photodynamic therapy. Abstract Text:

Yihui Chen,Kei Ohkubo,Min Zhang,E Wenbo,Weiguo Liu,Suresh K Pandey,Michael Ciesielski,Heinz Baumann,Tracy Erin,Shunichi Fukuzumi,Karl M Kadish,Robert Fenstermaker,Allan Oseroff,Ravindra K Pandey,Yihui Chen,Kei Ohkubo,Min Zhang,E Wenbo,Weiguo Liu,Suresh K Pandey,Michael Ciesielski,Heinz Baumann,Tracy Erin,Shunichi Fukuzumi,Karl M Kadish,Robert Fenstermaker,Allan Oseroff,Ravindra K Pandey,

The photophysical, electrochemical and spectroscopic characteristics of a conjugate of 3-devinyl-3-(1'-hexyloxyethyl)pyropheophorbide-a (HPPH) and a cyanine dye have been investigated both as a linked conjugate and as individual components. A photoexcitation of the HPPH moiety of the conjugate results in electron transfer from the singlet excited state of HPPH ((1)HPPH*) to the cyanine dye as well as that from the cyanine dye to (1)HPPH* and is followed in both cases by facile back electron transfer to the ground state as indicated by time-resolved fluorescence and transient absorption measurements. Intersystem crossing to the triplet excited state ((3)HPPH*) competes with the electron transfer and (3)HPPH* is quenched by oxygen to produce singlet oxygen ((1)O(2)), leading to specific covalent cross-linking of the nonactivated signal transducer and activator of transcription (STAT-3). In contrast to excitation of the HPPH moiety, photoexcitation of the cyanine dye unit results in a strong emission at 875 nm, which can be used for efficient tumor imaging. Compared to HPPH alone, the presence of the cyanine dye moiety in the conjugate produces a significantly higher uptake in tumors than in skin. Thus, the HPPH-cyanine dye conjugate can be used as a dual tumor imaging and photodynamic therapy agent.

Photophysical, electrochemical characteristics and cross-linking of STAT-3 protein by an efficient bifunctional agent for fluorescence image-guided photodynamic therapy. Publishing Authors By Initials

Y Chen,K Ohkubo,M Zhang,E Wenbo,W Liu,SK Pandey,M Ciesielski,H Baumann,T Erin,S Fukuzumi,KM Kadish,R Fenstermaker,A Oseroff,RK Pandey,Y Chen,K Ohkubo,M Zhang,E Wenbo,W Liu,SK Pandey,M Ciesielski,H Baumann,T Erin,S Fukuzumi,KM Kadish,R Fenstermaker,A Oseroff,RK Pandey,

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Photophysical, electrochemical characteristics and cross-linking of STAT-3 protein by an efficient bifunctional agent for fluorescence image-guided photodynamic therapy. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Photochemical & photobiological sciences : Officia

VOLUME: 6

Page Numbers: 1257-67

Journal Abbreviation: Photochem. Photobiol. Sci.

ISSN: 1474-905X

DAY: 24

MONTH: 09

YEAR: 2007

Photophysical, electrochemical characteristics and cross-linking of STAT-3 protein by an efficient bifunctional agent for fluorescence image-guided photodynamic therapy. Information

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LANGUAGE: eng

NlmUniqueID: 101124451

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Grant and Affiliation Information for Photophysical, electrochemical characteristics and cross-linking of STAT-3 protein by an efficient bifunctional agent for fluorescence image-guided photodynamic therapy.

AFFILIATION: Photodynamic Therapy Center, Roswell Park Cancer Institute, Buffalo, NY 14263. ravindra.pandey@roswellpark.org.

Country: England

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MEDLINETA: Photochem Photobiol Sci

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