Photonic explorers based on multifunctional nanoplatforms for biosensing and photodynamic therapy.

Photonic explorers based on multifunctional nanoplatforms for biosensing and photodynamic therapy. Research Abstract Details 

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Photonic explorers based on multifunctional nanoplatforms for biosensing and photodynamic therapy. Abstract Text:

Yong-Eun Lee Koo,Wenzhe Fan,Hoejin Hah,Hao Xu,Dan Orringer,Brian Ross,Alnawaz Rehemtulla,Martin A Philbert,Raoul Kopelman,

Nanoparticle-based photonic explorers have been developed for intracellular sensing and photodynamic therapy (PDT). The design employs nanoparticles made of various matrices as multifunctional nanoplatforms, loading active components by encapsulation or covalent attachment. The nanoplatform for biosensing has been successfully applied to intracellular measurements of important ionic and molecular species. The nanoplatform for PDT has shown high therapeutic efficacy in a rat 9L gliosarcoma model. Specifically, a multifunctional nanoplatform that encompasses magnetic resonance imaging (MRI) and PDT agents inside, as well as targeting ligands on the surface, has been developed and applied in vivo, resulting in much improved MRI contrast enhancement and PDT efficacy.

Photonic explorers based on multifunctional nanoplatforms for biosensing and photodynamic therapy. Publishing Authors By Initials

YE Koo,W Fan,H Hah,H Xu,D Orringer,B Ross,A Rehemtulla,MA Philbert,R Kopelman,

For similar natural sciences: physics: nuclear physics: elementary particles: photons research abstracts see: natural sciences: physics: nuclear physics: elementary particles: photons research

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Photonic explorers based on multifunctional nanoplatforms for biosensing and photodynamic therapy. Journal Published:

PUBLICATION TYPE: Review

Journal: Applied optics

VOLUME: 46

Page Numbers: 1924-30

Journal Abbreviation:

ISSN: 0003-6935

DAY: 1

MONTH: Apr

YEAR: 2007

Photonic explorers based on multifunctional nanoplatforms for biosensing and photodynamic therapy. Information

Number of References: 45

LANGUAGE: eng

NlmUniqueID: 247660

Photonic explorers based on multifunctional nanoplatforms for biosensing and photodynamic therapy. Keywords Mesh Terms:

KEYWORDS: Photons

MESH TERMS: therapeutic use

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Grant and Affiliation Information for Photonic explorers based on multifunctional nanoplatforms for biosensing and photodynamic therapy.

AFFILIATION: University of Michigan, Michigan 48109, USA. yeleekoo@umich.edu

Country: United States

AGENCY: United States NCI

GRANT: N01-CO-37123

ACRONYM: CO

MEDLINETA: Appl Opt

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