Photoirradiation of polycyclic aromatic hydrocarbons with UVA light - a pathway leading to the generation of reactive oxygen species, lipid peroxidation, and dna damage.

Photoirradiation of polycyclic aromatic hydrocarbons with UVA light - a pathway leading to the generation of reactive oxygen species, lipid peroxidation, and dna damage. Research Abstract Details 

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Photoirradiation of polycyclic aromatic hydrocarbons with UVA light - a pathway leading to the generation of reactive oxygen species, lipid peroxidation, and dna damage. Abstract Text:

Hongtao Yu,Qingsu Xia,Jian Yan,Diogenes Herreno-Saenz,Yuh-Shen Wu,I-Wah Tang,Peter P Fu,Hongtao Yu,Qingsu Xia,Jian Yan,Diogenes Herreno-Saenz,Yuh-Shen Wu,I-Wah Tang,Peter P Fu,

Polycyclic aromatic hydrocarbons (PAHs) are a class of genotoxic environmental contaminants. We have long been interested in determining the mechanisms by which PAHs induce genotoxicity. Although the metabolic activation of PAHs leading to biological activities has been well studied, the photo-induced activation pathway has seldom reported. In this paper, we review the study of photoirradiation of PAHs with UVA irradiation results in (i) cytotoxicity and DNA damage (ii) DNA single strand cleavage; (iii) formation of 8-hydroxy-2'-deoxyguanosine adduct (8-OHdG), and (iv) formation of lipid peroxidation. Evidence has been shown that these photobiological activities are mediated by reactive oxygen species (ROS).

Photoirradiation of polycyclic aromatic hydrocarbons with UVA light - a pathway leading to the generation of reactive oxygen species, lipid peroxidation, and dna damage. Publishing Authors By Initials

H Yu,Q Xia,J Yan,D Herreno-Saenz,YS Wu,IW Tang,PP Fu,H Yu,Q Xia,J Yan,D Herreno-Saenz,YS Wu,IW Tang,PP Fu,

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Photoirradiation of polycyclic aromatic hydrocarbons with UVA light - a pathway leading to the generation of reactive oxygen species, lipid peroxidation, and dna damage. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: International journal of environmental research an

VOLUME: 3

Page Numbers: 348-54

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ISSN: 1661-7827

DAY: 12

MONTH: Dec

YEAR: 2006

Photoirradiation of polycyclic aromatic hydrocarbons with UVA light - a pathway leading to the generation of reactive oxygen species, lipid peroxidation, and dna damage. Information

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LANGUAGE: eng

NlmUniqueID: 101238455

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Grant and Affiliation Information for Photoirradiation of polycyclic aromatic hydrocarbons with UVA light - a pathway leading to the generation of reactive oxygen species, lipid peroxidation, and dna damage.

AFFILIATION: Department of Chemistry, Jackson State University, Jackson, MS 39217, USA. hongtao.yu@jsums.edu

Country: Switzerland

AGENCY: United States NIGMS

GRANT: S06 GM08047

ACRONYM: GM

MEDLINETA: Int J Environ Res Public Healt

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