Photofrin uptake in the tumor and normal tissues of patients receiving intraperitoneal photodynamic therapy.

Photofrin uptake in the tumor and normal tissues of patients receiving intraperitoneal photodynamic therapy. Research Abstract Details 

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Photofrin uptake in the tumor and normal tissues of patients receiving intraperitoneal photodynamic therapy. Abstract Text:

Stephen M Hahn,Mary E Putt,James Metz,Daniel B Shin,Elizabeth Rickter,Chandrakala Menon,Debbie Smith,Eli Glatstein,Douglas L Fraker,Theresa M Busch,

PURPOSE: A phase II trial of Photofrin-mediated i.p. photodynamic therapy shown in a previous report limited efficacy and significant acute, but not chronic, toxicity. A secondary aim of this trial and the subject of this report is to determine Photofrin uptake in tumor and normal tissues. EXPERIMENTAL DESIGN: Patients received Photofrin, 2.5 mg/kg, i.v., 48 hours before debulking surgery. Photofrin uptake was measured by spectroflurometric analysis of drug extracted from tumor and normal tissues removed at surgery. Differences in drug uptake among these tissues were statistically considered using mixed-effects models. RESULTS: Photofrin concentration was measured in 301 samples collected from 58 of 100 patients enrolled on the trial. In normal tissues, drug uptake significantly (P<0.0001) differed as a function of seven different tissue types. In the toxicity-limiting tissue of intestine, the model-based mean (SE) Photofrin level was 2.70 ng/mg (0.32 ng/mg) and 3.42 ng/mg (0.24 ng/mg) in full-thickness large and small intestine, respectively. In tumors, drug uptake significantly (P=0.0015) differed as a function of patient cohort: model-based mean Photofrin level was 3.32 to 5.31 ng/mg among patients with ovarian, gastric, or small bowel cancer; 2.09 to 2.45 ng/mg among patients with sarcoma and appendiceal or colon cancer; and 0.93 ng/mg in patients with pseudomyxoma. Ovarian, gastric, and small bowel cancers showed significantly higher Photofrin uptake than full-thickness large and/or small intestine. However, the ratio of mean drug level in tumor versus intestine was modest (

Photofrin uptake in the tumor and normal tissues of patients receiving intraperitoneal photodynamic therapy. Publishing Authors By Initials

SM Hahn,ME Putt,J Metz,DB Shin,E Rickter,C Menon,D Smith,E Glatstein,DL Fraker,TM Busch,

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Photofrin uptake in the tumor and normal tissues of patients receiving intraperitoneal photodynamic therapy. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Clinical cancer research : an official journal of

VOLUME: 12

Page Numbers: 5464-70

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ISSN: 1078-0432

DAY: 15

MONTH: Sep

YEAR: 2006

Photofrin uptake in the tumor and normal tissues of patients receiving intraperitoneal photodynamic therapy. Information

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LANGUAGE: eng

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AFFILIATION: Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6072, USA.

Country: United States

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MEDLINETA: Clin Cancer Res

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