Photoacoustic probing of fluorophore excited state lifetime with application to oxygen sensing.

Photoacoustic probing of fluorophore excited state lifetime with application to oxygen sensing. Research Abstract Details 

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Photoacoustic probing of fluorophore excited state lifetime with application to oxygen sensing. Abstract Text:

A new method is developed to perform local measurements of fluorophore excited state lifetimes in turbid media without collecting the fluorescence emission. The method is based on a pump-probe approach where a first laser pulse excites the dye and then a second laser pulse is used for photoacoustic probing of the transient absorption. The photoacoustic response generated by the probe pulse is recorded by an ultrasound receiver. Repeating the measurement for increasing pump-probe time delays yields a series of photoacoustic signals that are used to extract the lifetime of the excited state. The method is validated by measuring the lifetime of an oxygen sensitive dye solution at different concentrations of dissolved oxygen. The dye is pumped with a 532-nm pulsed laser and the transient absorption at 740 nm is probed using a second pulsed laser system. The photoacoustic-based results are in close agreement with those obtained from time-dependent fluorescent measurements. The method can be extended to photoacoustic lifetime imaging by using a receiver array instead of a single receiver. Potential applications of this method include tissue oxygen imaging for cancer diagnostics and mapping molecular events such as resonant energy transfer and ion collisions in a biological environment.

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MEDLINE DATE: 2008 May-Jun

Photoacoustic probing of fluorophore excited state lifetime with application to oxygen sensing. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biomedical optics

VOLUME: 13

Page Numbers: 034023

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ISSN: 1083-3668

DAY: 8

MONTH: 07

YEAR: 2008

Photoacoustic probing of fluorophore excited state lifetime with application to oxygen sensing. Information

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LANGUAGE: eng

NlmUniqueID: 9605853

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Grant and Affiliation Information for Photoacoustic probing of fluorophore excited state lifetime with application to oxygen sensing.

AFFILIATION: University of Michigan, Department of Biomedical Engineering, 2200 Bonisteel Boulevard, Ann Arbor, Michigan 48109-2099.

Country: United States

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MEDLINETA: J Biomed Opt

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