Photo-crosslinkable, thermo-sensitive and biodegradable pluronic hydrogels for sustained release of protein.

Photo-crosslinkable, thermo-sensitive and biodegradable pluronic hydrogels for sustained release of protein. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Photo-crosslinkable, thermo-sensitive and biodegradable pluronic hydrogels for sustained release of protein. Abstract Text:

Jun Bae Lee,Jun Jin Yoon,Doo Sung Lee,Tae Gwan Park,

Thermo-sensitive and biodegradable hydrogels based on Pluronic tri-block copolymers were prepared by a photo-polymerization method. Two terminal hydroxyl groups in Pluronic F-127 were acrylated to form a Pluronic macromer. Photo-cross-linked Pluronic hydrogels prepared by UV radiation showed a gradually decreased swelling ratio with increasing temperature and exhibited a thermally-responsive change in the swelling ratio when the temperature was cycled between 10 degrees C and 37 degrees C. These hydrogels degraded slowly due to the cleavage of ester linkage in the acrylated Pluronic terminal end. When lysozyme, a model protein drug, was loaded in the hydrogels, bi-phasic protein release profiles were attained: a burst-free and rapid controlled release profile was initially observed for a one week period and a much slower sustained release was followed thereafter. The release rates could be controlled by varying the amount of Pluronic macromer for photo-polymerization.

Photo-crosslinkable, thermo-sensitive and biodegradable pluronic hydrogels for sustained release of protein. Publishing Authors By Initials

JB Lee,JJ Yoon,DS Lee,TG Park,

For similar environment and public health: environment: environment, controlled: temperature research abstracts see: environment and public health: environment: environment, controlled: temperature research

PUBMED ID PMID:

MEDLINE DATE:

Photo-crosslinkable, thermo-sensitive and biodegradable pluronic hydrogels for sustained release of protein. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biomaterials science. Polymer edition

VOLUME: 15

Page Numbers: 1571-83

Journal Abbreviation:

ISSN: 0920-5063

DAY: 20

MONTH: 02

YEAR: 2004

Photo-crosslinkable, thermo-sensitive and biodegradable pluronic hydrogels for sustained release of protein. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9007393

Photo-crosslinkable, thermo-sensitive and biodegradable pluronic hydrogels for sustained release of protein. Keywords Mesh Terms:

KEYWORDS: Temperature

MESH TERMS: administration & dosage

Chemical & Substance for Abstract: Photo-crosslinkable, thermo-sensitive and biodegradable pluronic hydrogels for sustained release of protein. Information

Substance Name: Muramidase

Registry Number: EC 3.2.1.17

Grant and Affiliation Information for Photo-crosslinkable, thermo-sensitive and biodegradable pluronic hydrogels for sustained release of protein.

AFFILIATION: Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701, South Korea.

Country: Netherlands

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Biomater Sci Polym Ed

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Photo-crosslinkable, thermo-sensitive and biodegradable pluronic hydrogels for sustained release of protein Related Publications

• Abc amino acids: design, synthesis, and properties of new photoelastic amino acids.
• Age-related stereotypes: a comparison of American and Chinese cultures.
• Categorical organization in free recall across culture and age.
• Duration of thawing on post thaw acrosome morphology and motility of boar spermatozoa frozen in 5-ml maxi-straws.
• Epstein-Barr virus infected natural killer cell lymphoma in a patient with hypersensitivity to mosquito bite.
• Expression of mucin genes in chronic ethmoiditis.
• Inhibition of IL-8 production by green tea polyphenols in human nasal fibroblasts and a549 epithelial cells.
• Interactions of vitamin E and penicillamine in the treatment of hereditary avian muscular dystrophy.
• Molecular cloning and characterization of a novel mouse betaPix isoform.
• Physiologic estrogen receptor alpha signaling in non-tumorigenic human mammary epithelial cells.
• Post-traumatic pseudomeningocele presenting as a cyst of external auditory canal: report of a case.
• Selection of neural differentiation-specific genes by comparing profiles of random differentiation.
• Source memory, aging and culture.
• Stimulation of melanogenesis by scoparone in B16 melanoma cells.
• Stunning and I-123 use for diagnostic whole body scanning.
• [A case of adenosquamous carcinoma of the papilla of Vater]
• [A case of colon cancer associated with Crohn's disease]
• [A case of gastric variceal bleeding due to pancreatic cancer]
• [A comparative study on family perception between abused children and normal children by Kinetic Family Drawing]
• [A comparison of interventions recorded in nursing notes between acute and subacute stage after a cerebrovascular accident]
• [A study on health perception and health promoting behavior in chronic back pain patients]
• [Comparison of influential variables for smoking temptation between adolescent and adult smokers]
• [Detection of liver metastases and recurrence using PET-CT scan in a patient with rectal cancer]
• [Effects of on education program for nurses on the use of restraints]
• [Gossypiboma (Textiloma) due to retained surgical gauze]
• [Primary biliary cirrhosis]
• [Process of seeking positive life of patients with Parkinson's disease]
• [Research trend of complementary and alternative medicine]
• [The effects of a recovery education program on rehabilitation motivation, symptoms, and function for schizophrenic patients]
• [The effects of a rehabilitation program on physical health, physiological indicator and quality of life in breast cancer mastectomy patients]