Photic induction of Period gene expression is reduced in Clock mutant mice.

Photic induction of Period gene expression is reduced in Clock mutant mice. Research Abstract Details 

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Photic induction of Period gene expression is reduced in Clock mutant mice. Abstract Text:

L P Shearman,D R Weaver,

The Clock mutation leads to abnormal circadian behavior and defective transcriptional activity of CLOCK, a basic helix-loop-helix (bHLH)/PAS protein. In situ hybridization was used to assess whether the Clock mutation affects the photic induction of mPer1, mPer2, and c-fos in the mouse suprachiasmatic nucleus (SCN). Exposure of wild-type mice to a 15 min light pulse at night rapidly induced expression of c-fos mRNA, with mPer1 and mPer2 mRNAs peaking later. Light exposure also increased c-fos, mPer1 and mPer2 mRNA levels in the SCN of homozygous Clock mutant mice, but the amplitude of the response to light was significantly reduced. Clock appears to play a role in circadian photoreception that is distinct from its role in the circadian oscillatory mechanism.

Photic induction of Period gene expression is reduced in Clock mutant mice. Publishing Authors By Initials

LP Shearman,DR Weaver,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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Photic induction of Period gene expression is reduced in Clock mutant mice. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Neuroreport

VOLUME: 10

Page Numbers: 613-8

Journal Abbreviation: Neuroreport

ISSN: 0959-4965

DAY: 25

MONTH: Feb

YEAR: 1999

Photic induction of Period gene expression is reduced in Clock mutant mice. Information

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LANGUAGE: eng

NlmUniqueID: 9100935

Photic induction of Period gene expression is reduced in Clock mutant mice. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: genetics

Chemical & Substance for Abstract: Photic induction of Period gene expression is reduced in Clock mutant mice. Information

Substance Name: Transcription Factors

Registry Number: 0

Grant and Affiliation Information for Photic induction of Period gene expression is reduced in Clock mutant mice.

AFFILIATION: Pediatric Service, Massachusetts General Hospital, Boston 02114, USA.

Country: ENGLAND

AGENCY: United States NICHD

GRANT: R37HD14427

ACRONYM: HD

MEDLINETA: Neuroreport

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