Phosphorylation of ryanodine receptors in rat myocytes during beta-adrenergic stimulation.

Phosphorylation of ryanodine receptors in rat myocytes during beta-adrenergic stimulation. Research Abstract Details 

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Phosphorylation of ryanodine receptors in rat myocytes during beta-adrenergic stimulation. Abstract Text:

A Yoshida,M Takahashi,T Imagawa,M Shigekawa,H Takisawa,T Nakamura,

We studied beta-adrenergic agonist-stimulated phosphorylation of the ryanodine receptor in rat cardiac myocytes. The ryanodine receptor solubilized from myocytes and immunoprecipitated by a monoclonal antibody against canine cardiac ryanodine receptor was phosphorylated by the catalytic subunit of cAMP-dependent protein kinase (PKA). Incubation of saponin-permeabilized myocytes with [gamma-32P]ATP also induced ryanodine receptor phosphorylation, which was enhanced significantly in the presence of isoproterenol. This stimulating action of isoproterenol was suppressed by the beta-adrenergic antagonist, propranolol. On the other hand, exogenously added cAMP caused a much larger stimulation of phosphorylation of the ryanodine receptor in permeabilized myocytes. The beta-agonist-induced phosphorylation of the ryanodine receptor was also observed in intact myocytes from the newborn rat heart. These results suggest that the ryanodine receptor is phosphorylated by PKA during beta-adrenergic stimulation of cardiac myocytes.

Phosphorylation of ryanodine receptors in rat myocytes during beta-adrenergic stimulation. Publishing Authors By Initials

A Yoshida,M Takahashi,T Imagawa,M Shigekawa,H Takisawa,T Nakamura,

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Phosphorylation of ryanodine receptors in rat myocytes during beta-adrenergic stimulation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biochemistry

VOLUME: 111

Page Numbers: 186-90

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Feb

YEAR: 1992

Phosphorylation of ryanodine receptors in rat myocytes during beta-adrenergic stimulation. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Phosphorylation of ryanodine receptors in rat myocytes during beta-adrenergic stimulation. Keywords Mesh Terms:

KEYWORDS: Tritium

MESH TERMS: diagnostic use

Chemical & Substance for Abstract: Phosphorylation of ryanodine receptors in rat myocytes during beta-adrenergic stimulation. Information

Substance Name: Isoproterenol

Registry Number: 7683-59-2

Grant and Affiliation Information for Phosphorylation of ryanodine receptors in rat myocytes during beta-adrenergic stimulation.

AFFILIATION: Department of Biology, Faculty of Science, Osaka University.

Country: JAPAN

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MEDLINETA: J Biochem

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