[Phosphorylated JNK mediated apoptosis induced by all trans retinoid acid in human retinoblastoma cell line]

[Phosphorylated JNK mediated apoptosis induced by all trans retinoid acid in human retinoblastoma cell line] Research Abstract Details 

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[Phosphorylated JNK mediated apoptosis induced by all trans retinoid acid in human retinoblastoma cell line] Abstract Text:

Hong-bo Min,Jian-wen Wang,Ji-hu Sun,Shi-zhong Bu,Qin Huang,

OBJECTIVE: To investigate the mechanism of all trans retinoid acid (ATRA) inhibition of cell growth and induction of apoptosis in human retinoblastoma Y79 cells. METHODS: Antiproliferating effects of ATRA on Y79 cells were studied by (3)H-thymidine incorporation. Cell cycle analysis was performed by flow cytometry, apoptosis of the ATRA-treated cells was determined by DNA fragmentation analysis and JNK phosphorylation analyzed by Western blot. RESULTS: After 36h treatment of 1 micro mol/L ATRA, (3)H-thymidine incorporation decreased to 40% with Y79 cells arrested in G(0)/G(1) and Sub-G(1) peak appeared. DNA ladder was observed in DNA fragmentation analysis after 36h treatment of ATRA. Curcumin, a JNK blocker, blocked the apoptosis and the growth inhibition induced by ATRA. JNK was phosphorylated in 10 to 20 min. CONCLUSION: ATRA can induce the apoptosis in Y79 cells by phosphorylation of JNK, which suggests that ATRA may have clinical application prospects for treatment of retinoblastoma.

[Phosphorylated JNK mediated apoptosis induced by all trans retinoid acid in human retinoblastoma cell line] Publishing Authors By Initials

HB Min,JW Wang,JH Sun,SZ Bu,Q Huang,

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[Phosphorylated JNK mediated apoptosis induced by all trans retinoid acid in human retinoblastoma cell line] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua zhong liu za zhi [Chinese journal of onco

VOLUME: 25

Page Numbers: 130-3

Journal Abbreviation: Zhonghua Zhong Liu Za Zhi

ISSN: 0253-3766

DAY: 10

MONTH: Mar

YEAR: 2003

[Phosphorylated JNK mediated apoptosis induced by all trans retinoid acid in human retinoblastoma cell line] Information

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LANGUAGE: chi

NlmUniqueID: 7910681

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Grant and Affiliation Information for [Phosphorylated JNK mediated apoptosis induced by all trans retinoid acid in human retinoblastoma cell line]

AFFILIATION: Department of Ophthalmology, 455 Hospital, PLA, Shanghai 200052, China.

Country: China

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MEDLINETA: Zhonghua Zhong Liu Za Zhi

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