Phospholipases A2 isolated from Micrurus lemniscatus coral snake venom: Behavioral, electroencephalographic, and neuropathological aspects.

Phospholipases A2 isolated from Micrurus lemniscatus coral snake venom: Behavioral, electroencephalographic, and neuropathological aspects. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Phospholipases A2 isolated from Micrurus lemniscatus coral snake venom: Behavioral, electroencephalographic, and neuropathological aspects. Abstract Text:

The present study evaluated four phospholipase A2 (PLA2) (Mlx-8, Mlx-9, Mlx-11 and Mlx-12) isolated from Micrurus lemniscatus snake venom (Elapidae). The effects of intrahippocampal administration of these toxins have been determined on behavior, electroencephalography, and neuronal degeneration in rats. These four PLA2 toxins induced motor and EEG alterations in a dose-dependent manner. Behavioral convulsions were characterized by clonic movements and were often accompanied by EEG alterations. Mlx toxins were convulsive but weakly epileptogenic, since low rates of seizure discharges were observed in EEG records. Neuronal injury seemed to depend on the dose of the toxin used. The highest doses of toxins caused severe intoxication and death of some animals. The injury of hippocampal cells was characterized by massive neuronal loss and hippocampal gliosis. A high occurrence of compulsive scratching was observed. Moreover, the onset of seizures induced by Mlx toxins was markedly delayed. The similarities between the effects of Mlx PLA2s and those isolated from other Elapidae snakes venoms suggest that their toxicity are probably due to their specific binding to neuronal membranes and to the catalysis of phospholipid hydrolysis, producing lysophospholipids and fatty acids. These compounds likely disturb the membrane conformation, causing a marked increase in the release of neurotransmitters and concurrent inhibition of vesicle fission and recycling. These toxins can be a useful tool to investigate properties of endogenous secretory PLA2s and therefore may be important both to study mechanisms involved in neurotransmitter release at nerve terminals and to explain the convulsive properties of PLA2s toxins.

Phospholipases A2 isolated from Micrurus lemniscatus coral snake venom: Behavioral, electroencephalographic, and neuropathological aspects. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Phospholipases A2 isolated from Micrurus lemniscatus coral snake venom: Behavioral, electroencephalographic, and neuropathological aspects. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Brain research bulletin

VOLUME: 75

Page Numbers: 629-39

Journal Abbreviation: Brain Res. Bull.

ISSN: 0361-9230

DAY: 20

MONTH: 11

YEAR: 2007

Phospholipases A2 isolated from Micrurus lemniscatus coral snake venom: Behavioral, electroencephalographic, and neuropathological aspects. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7605818

Phospholipases A2 isolated from Micrurus lemniscatus coral snake venom: Behavioral, electroencephalographic, and neuropathological aspects. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Phospholipases A2 isolated from Micrurus lemniscatus coral snake venom: Behavioral, electroencephalographic, and neuropathological aspects. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Phospholipases A2 isolated from Micrurus lemniscatus coral snake venom: Behavioral, electroencephalographic, and neuropathological aspects.

AFFILIATION: Laboratory of Pharmacology, Butantan Institute, Av. Dr. Vital Brasil 1500, São Paulo, SP 05503 900, Brazil.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Brain Res Bull

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Phospholipases A2 isolated from Micrurus lemniscatus coral snake venom: Behavioral, electroencephalographic, and neuropathological aspects Related Publications

• ATP7B copper-regulated traffic and association with the tight junctions: copper excretion into the bile.
• Amelioration of early cognitive deficits by aged garlic extract in Alzheimer's transgenic mice.
• Angiotensin-converting enzyme insertion/deletion polymorphism is not associated with susceptibility and outcome in sepsis and acute respiratory distress syndrome.
• Bolivia's economy--an update.
• CNS GLP-1 regulation of peripheral glucose homeostasis.
• Comparison of the infiniti vision and the series 20,000 legacy systems.
• Ecological niche dimensionality and the evolutionary diversification of stick insects.
• Language of administration and neuropsychological test performance in neurologically intact Hispanic American bilingual adults.
• Live-animal imaging of renal function by multiphoton microscopy.
• Marketing infant formula through hospitals: the impact of commercial hospital discharge packs on breastfeeding.
• On practical issues about interference in telecare applications based on different wireless technologies.
• Oxidative status in neuroblastoma: a source of stress?
• P26.04: The Helical Ventricular Myocardial Band-Applications to the fetal heart and Congenital Heart Disease.
• Pharmacophotonics: utilizing multi-photon microscopy to quantify drug delivery and intracellular trafficking in the kidney.
• Phospholipases A2 isolated from Micrurus lemniscatus coral snake venom: Behavioral, electroencephalographic, and neuropathological aspects.
• Quantifying dynamic kidney processes utilizing multi-photon microscopy.
• Reproductive emergencies in camelids.
• Response of mice to the inoculations of both Candida albicans and Escherichia coli. I. The enhancement phenomenon.
• Thalidomide and Thalidomide Transformed by pH-Dependent Hydrolysis or by Liver Enzyme Treatment Does Not Impede the Proliferation of Endothelial Cells.
• The effect of conditioning of fused-silica capillaries on their electrophoretic performance.
• Topical review: Temporomandibular disorders in an integral otic symptom model.
• [Current methods of programming to choose from among the alternatives in medical care projects]
• [Environmental sanitation planning]
• [Fetal opisthotonos in face presentation.]
• [Not Available.]
• [Not Available.]
• [Otological symptoms among patients with temporomandibular joint disorders.]
• [Prevalence of fascioliasis in humans, horses, pigs, and wild rabbits in 3 Chilean provinces]
• [SU-4885 in pituitary patients.]
• [Toxic effect of beta-cipermethrin, deltamethrin and fenitrothion in colonies of Triatoma dimidiata (Latreille, 1811) and Triatoma maculata (Erichson, 1848) (Hemiptera, Reduviidae)]