Phospholipase C-eta enzymes as putative protein kinase C and Ca2+ signalling components in neuronal and neuroendocrine tissues.

Phospholipase C-eta enzymes as putative protein kinase C and Ca2+ signalling components in neuronal and neuroendocrine tissues. Research Abstract Details 

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Phospholipase C-eta enzymes as putative protein kinase C and Ca2+ signalling components in neuronal and neuroendocrine tissues. Abstract Text:

Alan J Stewart,Kevin Morgan,Colin Farquharson,Robert P Millar,Alan J Stewart,Kevin Morgan,Colin Farquharson,Robert P Millar,

Phosphoinositol-specific phospholipase C enzymes (PLCs) are central to inositol lipid signalling pathways, facilitating intracellular Ca2+ release and protein kinase C activation. A sixth class of phosphoinositol-specific PLC with a novel domain structure, PLC-eta (PLCeta) has recently been discovered in mammals. Recent research, reviewed here, shows that this class consists of two enzymes, PLCeta1 and PLCeta2. Both enzymes hydrolyze phosphatidylinositol 4,5-bisphosphate and are more sensitive to Ca2+ than other PLC isozymes and are likely to mediate G-protein-coupled receptor (GPCR) signalling pathways. Both enzymes are expressed in neuron-enriched regions, being abundant in the brain. We demonstrate that they are also expressed in neuroendocrine cell lines. PLCeta enzymes therefore represent novel proteins influencing intracellular Ca2+ dynamics and protein kinase C activation in the brain and neuroendocrine systems as putative mediation of GPCR regulation.

Phospholipase C-eta enzymes as putative protein kinase C and Ca2+ signalling components in neuronal and neuroendocrine tissues. Publishing Authors By Initials

AJ Stewart,K Morgan,C Farquharson,RP Millar,AJ Stewart,K Morgan,C Farquharson,RP Millar,

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Phospholipase C-eta enzymes as putative protein kinase C and Ca2+ signalling components in neuronal and neuroendocrine tissues. Journal Published:

PUBLICATION TYPE: Review

Journal: Neuroendocrinology

VOLUME: 86

Page Numbers: 243-8

Journal Abbreviation: Neuroendocrinology

ISSN: 1423-0194

DAY: 30

MONTH: 08

YEAR: 2007

Phospholipase C-eta enzymes as putative protein kinase C and Ca2+ signalling components in neuronal and neuroendocrine tissues. Information

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LANGUAGE: eng

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AFFILIATION: MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen's Medical Research Institute, Edinburgh, UK. A.Stewart@hrsu.mrc.ac.uk

Country: Switzerland

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MEDLINETA: Neuroendocrinology

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