Phosphoinositide 3-kinase gamma participates in T cell receptor-induced T cell activation.

Phosphoinositide 3-kinase gamma participates in T cell receptor-induced T cell activation. Research Abstract Details 

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Phosphoinositide 3-kinase gamma participates in T cell receptor-induced T cell activation. Abstract Text:

Isabela ,Miriam ,Amit Kumar,Emilio Hirsch,Matthias Wymann,Ana C Carrera,Domingo F Barber,Isabela ,Miriam ,Amit Kumar,Emilio Hirsch,Matthias Wymann,Ana C Carrera,Domingo F Barber,

Class I phosphoinositide 3-kinases (PI3Ks) constitute a family of enzymes that generates 3-phosphorylated polyphosphoinositides at the cell membrane after stimulation of protein tyrosine (Tyr) kinase-associated receptors or G protein-coupled receptors (GPCRs). The class I PI3Ks are divided into two types: class I(A) p85/p110 heterodimers, which are activated by Tyr kinases, and the class I(B) p110gamma isoform, which is activated by GPCR. Although the T cell receptor (TCR) is a protein Tyr kinase-associated receptor, p110gamma deletion affects TCR-induced T cell stimulation. We examined whether the TCR activates p110gamma, as well as the consequences of interfering with p110gamma expression or function for T cell activation. We found that after TCR ligation, p110gamma interacts with G alpha(q/11), lymphocyte-specific Tyr kinase, and zeta-associated protein. TCR stimulation activates p110gamma, which affects 3-phosphorylated polyphosphoinositide levels at the immunological synapse. We show that TCR-stimulated p110gamma controls RAS-related C3 botulinum substrate 1 activity, F-actin polarization, and the interaction between T cells and antigen-presenting cells, illustrating a crucial role for p110gamma in TCR-induced T cell activation.

Phosphoinositide 3-kinase gamma participates in T cell receptor-induced T cell activation. Publishing Authors By Initials

I ,M ,A Kumar,E Hirsch,M Wymann,AC Carrera,DF Barber,I ,M ,A Kumar,E Hirsch,M Wymann,AC Carrera,DF Barber,

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Phosphoinositide 3-kinase gamma participates in T cell receptor-induced T cell activation. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of experimental medicine

VOLUME: 204

Page Numbers: 2977-87

Journal Abbreviation: J. Exp. Med.

ISSN: 1540-9538

DAY: 6

MONTH: 11

YEAR: 2007

Phosphoinositide 3-kinase gamma participates in T cell receptor-induced T cell activation. Information

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LANGUAGE: eng

NlmUniqueID: 2985109

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AFFILIATION: Department of Immunology and Oncology, Centro Nacional de Biotecnología/Consejo Superior de Investigaciones Cientificas, Madrid 28049, Spain.

Country: United States

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MEDLINETA: J Exp Med

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