Phosphatidylserine specific binding protein in rat brain: purification and characterization.

Phosphatidylserine specific binding protein in rat brain: purification and characterization. Research Abstract Details 

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Phosphatidylserine specific binding protein in rat brain: purification and characterization. Abstract Text:

T Nakaoka,N Kojima,T Hamamoto,N Kurosawa,Y C Lee,H Kawasaki,K Suzuki,S Tsuji,

A calcium-independent phosphatidylserine specific binding protein detected on liposome blotting analysis was purified from rat brain and revealed to be identical to myristoylated, alanine-rich C kinase substrate (MARCKS). MARCKS specifically binds to phosphatidylserine but not phosphatidylcholine. The binding of MARCKS to phosphatidylserine was abolished on protein kinase C-dependent phosphorylation. Since bacterially expressed MARCKS also specifically binds to phosphatidylserine, myristoylation of the N-terminal glycine seems not to be essential for the binding of MARCKS to phosphatidylserine. These data suggest that phosphatidylserine is a membranous target molecule of MARCKS.

Phosphatidylserine specific binding protein in rat brain: purification and characterization. Publishing Authors By Initials

T Nakaoka,N Kojima,T Hamamoto,N Kurosawa,YC Lee,H Kawasaki,K Suzuki,S Tsuji,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats research

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Phosphatidylserine specific binding protein in rat brain: purification and characterization. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 114

Page Numbers: 449-52

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Oct

YEAR: 1993

Phosphatidylserine specific binding protein in rat brain: purification and characterization. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Phosphatidylserine specific binding protein in rat brain: purification and characterization. Keywords Mesh Terms:

KEYWORDS: Rats

MESH TERMS: metabolism

Chemical & Substance for Abstract: Phosphatidylserine specific binding protein in rat brain: purification and characterization. Information

Substance Name: Protein Kinase C

Registry Number: EC 2.7.11.13

Grant and Affiliation Information for Phosphatidylserine specific binding protein in rat brain: purification and characterization.

AFFILIATION: Glyco Molecular Biology, Frontier Research Program, Institute of Physical and Chemical Research (RIKEN), Saitama.

Country: JAPAN

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MEDLINETA: J Biochem

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