Phorbol as a possible systemic promoting agent for skin carcinogenesis.

Phorbol as a possible systemic promoting agent for skin carcinogenesis. Research Abstract Details 

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Phorbol as a possible systemic promoting agent for skin carcinogenesis. Abstract Text:

In a repetition of a previous experiment, using this time a 20-fold higher dose of phorbol, administered i.p. as potential (systemic) promotor for skin carcinogenesis, 6/22 (27%) of the treated mice (after a single skin application of DMBA as initiator) developed papillomas, as compared to 1/20 (5%) in the DMBA control group. Though the difference is statistically no more than of borderline significance (P less than 0.05), it does raise the possibility that unesterified phorbol is, after all, a weak promotor for skin carcinogenesis. Abbreviations: DMBA equals 7,12-dimethylbenz(a)anthracene. TPA equals 12-0-tetradecanoyl-phorbol-13-acetate.

Phorbol as a possible systemic promoting agent for skin carcinogenesis. Publishing Authors By Initials

For similar organic chemicals: hydrocarbons: terpenes: diterpenes: phorbols: phorbol esters: tetradecanoylphorbol acetate research abstracts see: organic chemicals: hydrocarbons: terpenes: diterpenes: phorbols: phorbol esters: tetradecanoylphorbol acetate research

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Phorbol as a possible systemic promoting agent for skin carcinogenesis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zeitschrift für Krebsforschung und klinische Onkol

VOLUME: 85

Page Numbers: 79-82

Journal Abbreviation:

ISSN: 0084-5353

DAY: 2

MONTH: Jan

YEAR: 1976

Phorbol as a possible systemic promoting agent for skin carcinogenesis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 1276653

Phorbol as a possible systemic promoting agent for skin carcinogenesis. Keywords Mesh Terms:

KEYWORDS: Tetradecanoylphorbol Acetate

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Phorbol as a possible systemic promoting agent for skin carcinogenesis. Information

Substance Name: 9,10-Dimethyl-1,2-benzanthracene

Registry Number: 57-97-6

Grant and Affiliation Information for Phorbol as a possible systemic promoting agent for skin carcinogenesis.

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Country: GERMANY, WEST

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MEDLINETA: Z Krebsforsch Klin Onkol Cance

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• Phorbol as a possible systemic promoting agent for skin carcinogenesis.
• The carcinogenic action of 9,10-dimethyl-1,2-benzanthracene on the skin and subcutaneous tissues of the mouse, rabbit, rat and guinea pig.