Phenylimidazole derivatives as specific inhibitors of bacterial enoyl-acyl carrier protein reductase FabK.

Phenylimidazole derivatives as specific inhibitors of bacterial enoyl-acyl carrier protein reductase FabK. Research Abstract Details 

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Phenylimidazole derivatives as specific inhibitors of bacterial enoyl-acyl carrier protein reductase FabK. Abstract Text:

Tomohiro Ozawa,Hideo Kitagawa,Yasuo Yamamoto,Sho Takahata,Maiko Iida,Yumi Osaki,Keiko Yamada,Tomohiro Ozawa,Hideo Kitagawa,Yasuo Yamamoto,Sho Takahata,Maiko Iida,Yumi Osaki,Keiko Yamada,Tomohiro Ozawa,Hideo Kitagawa,Yasuo Yamamoto,Sho Takahata,Maiko Iida,Yumi Osaki,Keiko Yamada,

Bacterial enoyl-acyl carrier protein (ACP) reductases (FabI and FabK) catalyze the final step in each cycle of bacterial fatty acid biosynthesis and are attractive targets for the development of new antibacterial agents. Here, we report the development of novel FabK inhibitors with antibacterial activity against Streptococcus pneumoniae. Based on structure-activity relationship (SAR) studies of our screening hits, we have developed novel phenylimidazole derivatives as potent FabK inhibitors.

Phenylimidazole derivatives as specific inhibitors of bacterial enoyl-acyl carrier protein reductase FabK. Publishing Authors By Initials

T Ozawa,H Kitagawa,Y Yamamoto,S Takahata,M Iida,Y Osaki,K Yamada,T Ozawa,H Kitagawa,Y Yamamoto,S Takahata,M Iida,Y Osaki,K Yamada,T Ozawa,H Kitagawa,Y Yamamoto,S Takahata,M Iida,Y Osaki,K Yamada,

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Phenylimidazole derivatives as specific inhibitors of bacterial enoyl-acyl carrier protein reductase FabK. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bioorganic & medicinal chemistry

VOLUME: 15

Page Numbers: 7325-36

Journal Abbreviation: Bioorg. Med. Chem.

ISSN: 0968-0896

DAY: 4

MONTH: 09

YEAR: 2007

Phenylimidazole derivatives as specific inhibitors of bacterial enoyl-acyl carrier protein reductase FabK. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Phenylimidazole derivatives as specific inhibitors of bacterial enoyl-acyl carrier protein reductase FabK.

AFFILIATION: Medicinal Chemistry Research Laboratories, Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd, 760 Morooka-cho, Kohoku-ku, Yokohama 222-8567, Japan.

Country: England

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MEDLINETA: Bioorg Med Chem

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