Phenotypic and functional characterization of ex vivo T cell responses to the live attenuated herpes zoster vaccine.

Phenotypic and functional characterization of ex vivo T cell responses to the live attenuated herpes zoster vaccine. Research Abstract Details 

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Phenotypic and functional characterization of ex vivo T cell responses to the live attenuated herpes zoster vaccine. Abstract Text:

Julie Patterson-Bartlett,Myron J Levin,Nancy Lang,Florian P ,Rupert Vessey,Adriana Weinberg,Julie Patterson-Bartlett,Myron J Levin,Nancy Lang,Florian P ,Rupert Vessey,Adriana Weinberg,

To define the phenotypic characteristics and kinetics of T cell responses to a shingles vaccine in elderly individuals, 20 subjects > or =60 years of age received two doses of vaccine or placebo 6 weeks apart. VZV-specific T cell phenotypes and intracellular cytokines were determined by flow cytometry on blood mononuclear cells obtained pre-vaccination and up to 6 months after the second immunization. Results were compared with responses of five unvaccinated young adults. Pre-vaccination, elderly individuals had significantly lower VZV-specific effectors and cytokine-producing T cells compared with young adults. The vaccine significantly increased VZV-specific Th1, memory, early effector, and cutaneous homing receptor-bearing T cells.

Phenotypic and functional characterization of ex vivo T cell responses to the live attenuated herpes zoster vaccine. Publishing Authors By Initials

J Patterson-Bartlett,MJ Levin,N Lang,FP ,R Vessey,A Weinberg,J Patterson-Bartlett,MJ Levin,N Lang,FP ,R Vessey,A Weinberg,

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Phenotypic and functional characterization of ex vivo T cell responses to the live attenuated herpes zoster vaccine. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Vaccine

VOLUME: 25

Page Numbers: 7087-93

Journal Abbreviation: Vaccine

ISSN: 0264-410X

DAY: 15

MONTH: 08

YEAR: 2007

Phenotypic and functional characterization of ex vivo T cell responses to the live attenuated herpes zoster vaccine. Information

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LANGUAGE: eng

NlmUniqueID: 8406899

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Grant and Affiliation Information for Phenotypic and functional characterization of ex vivo T cell responses to the live attenuated herpes zoster vaccine.

AFFILIATION: Department of Pediatrics of the University of Colorado School of Medicine, Denver, CO 80262, USA.

Country: Netherlands

AGENCY: United States NCI

GRANT: P30 CA046934

ACRONYM: CA

MEDLINETA: Vaccine

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