Phenotypic analysis of receptor-ligand pairs on B-cells in B-chronic lymphocytic leukemia.

Phenotypic analysis of receptor-ligand pairs on B-cells in B-chronic lymphocytic leukemia. Research Abstract Details 

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Phenotypic analysis of receptor-ligand pairs on B-cells in B-chronic lymphocytic leukemia. Abstract Text:

Whole-blood three-color immunofluorescence analysis was used to investigate the role of CD5/CD72 and CD21/CD23 receptor-ligand pair formation on B-chronic lymphocytic leukemia (B-CLL) cells as well as sCD23 and bcl-2 oncoprotein expression in disease progression and activity and total tumor mass in B-cell chronic leukemia (B-CLL) patients. Thirty-four patients with B-CLL and 19 controls were included in the study. The majority of B-cells in B-CLL patients coexpressed CD5 and CD72 as well as the CD23 antigen. Unlike B-cells in B-CLL patients, B-cells in all healthy controls tested had high expression of CD21 antigen. We identified two groups of B-CLL patients according to high (n = 20) or low levels (n = 14) of CD21 expression on CD19+CD23+ B-cells. Only in the patients with high CD21 expression, were sCD23 levels positively correlated with factors known to have prognostic significance in B-CLL (Rai stage and TTM) and could, therefore, be used as a prognostic parameter for these B-CLL patients. Bcl-2 oncoprotein expression did not differ between these patient groups. We presumed that in patients with a lower expression of CD21 antigen, the contribution of the CD21 molecule to homotypic adhesion was lacking. Further studies are necessary to determine the possible association of higher expression of the CD21 antigen with disease progression and the aggressive character of the B-CLL.

Phenotypic analysis of receptor-ligand pairs on B-cells in B-chronic lymphocytic leukemia. Publishing Authors By Initials

For similar proteins: membrane proteins: receptors, cell surface: receptors, immunologic: receptors, fc: receptors, ige research abstracts see: proteins: membrane proteins: receptors, cell surface: receptors, immunologic: receptors, fc: receptors, ige research

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Phenotypic analysis of receptor-ligand pairs on B-cells in B-chronic lymphocytic leukemia. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Leukemia & lymphoma

VOLUME: 25

Page Numbers: 301-11

Journal Abbreviation: Leuk. Lymphoma

ISSN: 1042-8194

DAY: 6

MONTH: Apr

YEAR: 1997

Phenotypic analysis of receptor-ligand pairs on B-cells in B-chronic lymphocytic leukemia. Information

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LANGUAGE: eng

NlmUniqueID: 9007422

Phenotypic analysis of receptor-ligand pairs on B-cells in B-chronic lymphocytic leukemia. Keywords Mesh Terms:

KEYWORDS: Receptors, IgE

MESH TERMS: metabolism

Chemical & Substance for Abstract: Phenotypic analysis of receptor-ligand pairs on B-cells in B-chronic lymphocytic leukemia. Information

Substance Name: Receptors, IgE

Registry Number: 0

Grant and Affiliation Information for Phenotypic analysis of receptor-ligand pairs on B-cells in B-chronic lymphocytic leukemia.

AFFILIATION: Institute of Immunology, Zagreb, Croatia.

Country: SWITZERLAND

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MEDLINETA: Leuk Lymphoma

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