Phase shifts and Per gene expression in mouse suprachiasmatic nucleus.

Phase shifts and Per gene expression in mouse suprachiasmatic nucleus. Research Abstract Details 

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Phase shifts and Per gene expression in mouse suprachiasmatic nucleus. Abstract Text:

Lily Yan,Kelly J Hochstetler,Rae Silver,Abel Bult-Ito,

In mammals, circadian rhythms controlled by the suprachiasmatic nuclei are entrained by photic stimuli. To investigate the molecular mechanism of photic entrainment, we examined light-induced behavioral phase delays and associated changes in mPer1 and mPer2 gene expression in the suprachiasmatic nuclei of two mouse lines artificially selected for nest-building behavior. Big nest-builders show larger phase delays than small nest-builders. Light-induced mPer1 and mPer2 expression was examined in individual mice previously tested for phase shifting at circadian time 16. Light-induced mPer2 expression was significantly higher in big compared to small nest-builders. No difference was found between lines in light-induced mPer1 expression. The results suggest a more important role for mPer2 than for mPer1 gene expression in behavioral phase delays.

Phase shifts and Per gene expression in mouse suprachiasmatic nucleus. Publishing Authors By Initials

L Yan,KJ Hochstetler,R Silver,A Bult-Ito,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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Phase shifts and Per gene expression in mouse suprachiasmatic nucleus. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Neuroreport

VOLUME: 14

Page Numbers: 1247-51

Journal Abbreviation: Neuroreport

ISSN: 0959-4965

DAY: 1

MONTH: Jul

YEAR: 2003

Phase shifts and Per gene expression in mouse suprachiasmatic nucleus. Information

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LANGUAGE: eng

NlmUniqueID: 9100935

Phase shifts and Per gene expression in mouse suprachiasmatic nucleus. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: metabolism

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Substance Name: Transcription Factors

Registry Number: 0

Grant and Affiliation Information for Phase shifts and Per gene expression in mouse suprachiasmatic nucleus.

AFFILIATION: Department of Psychology, Columbia University, New York, NY 10027, USA.

Country: England

AGENCY: United States NINDS

GRANT: U54NS41069

ACRONYM: NS

MEDLINETA: Neuroreport

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