Phase II study of intra-arterial fluorouracil and mitomycin-C for liver metastases of colorectal cancer.

Phase II study of intra-arterial fluorouracil and mitomycin-C for liver metastases of colorectal cancer. Research Abstract Details 

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Phase II study of intra-arterial fluorouracil and mitomycin-C for liver metastases of colorectal cancer. Abstract Text:

U Metzger,W Weder,M Röthlin,F Largiadèr,

Effectiveness, toxicity and complications of 5-fluorouracil (FU) and mitomycin-C (MMC) treatment were analyzed in 30 patients with metastatic colorectal cancer confined to the liver. The treatment schedule was FU 2.0-2.5 g/day for 5 days followed by MMC 10 mg/m2 every 2 h on day 6 to a maximum total dose of 60 mg. Treatment courses were repeated every 6 weeks and were given on an outpatient basis via external pump and arterial port systems. In 30 fully evaluable patients, one complete response, 17 partial responses (overall response rate 60%), and stabilization of disease in 8 patients (26%) were obtained for a median duration of 13 months. Median overall survival was 18.2 months (25.5 months for responding patients, 15 months for nonresponders). Grade 1-2 toxicity (WHO classification) consisted of leukopenia (23%), mucositis (20%), nausea/vomiting (16%), and abdominal pain (10%). Two patients (7%) developed severe mucositis. No life-threatening side effects were observed; in particular, there was no sclerosing cholangitis or chemical hepatitis. Catheter-related problems (occlusion, displacement, rupture, infection) occurred in 10 patients (33%) at a median follow-up time of 12 months. We conclude that intra-arterial FU and MMC constitute an effective, safe, and nontoxic treatment in metastatic colorectal cancer confined to the liver. Catheter-related problems are the most important factors limiting treatment.

Phase II study of intra-arterial fluorouracil and mitomycin-C for liver metastases of colorectal cancer. Publishing Authors By Initials

U Metzger,W Weder,M Röthlin,F Largiadèr,

For similar investigative techniques: epidemiologic methods: data collection: vital statistics: mortality: survival rate research abstracts see: investigative techniques: epidemiologic methods: data collection: vital statistics: mortality: survival rate research

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Phase II study of intra-arterial fluorouracil and mitomycin-C for liver metastases of colorectal cancer. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Recent results in cancer research. Fortschritte de

VOLUME: 121

Page Numbers: 198-204

Journal Abbreviation: Recent Results Cancer Res.

ISSN: 0080-0015

DAY: 13

MONTH: 02

YEAR: 1991

Phase II study of intra-arterial fluorouracil and mitomycin-C for liver metastases of colorectal cancer. Information

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LANGUAGE: eng

NlmUniqueID: 44671

Phase II study of intra-arterial fluorouracil and mitomycin-C for liver metastases of colorectal cancer. Keywords Mesh Terms:

KEYWORDS: Survival Rate

MESH TERMS: administration & dosage

Chemical & Substance for Abstract: Phase II study of intra-arterial fluorouracil and mitomycin-C for liver metastases of colorectal cancer. Information

Substance Name: Fluorouracil

Registry Number: 51-21-8

Grant and Affiliation Information for Phase II study of intra-arterial fluorouracil and mitomycin-C for liver metastases of colorectal cancer.

AFFILIATION: Chirurgische Klinik, Triemli Spital, Zürich, Switzerland.

Country: GERMANY

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MEDLINETA: Recent Results Cancer Res

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