Phase I/II study of immunotherapy using autologous tumor lysate-pulsed dendritic cells in patients with metastatic renal cell carcinoma.

Phase I/II study of immunotherapy using autologous tumor lysate-pulsed dendritic cells in patients with metastatic renal cell carcinoma. Research Abstract Details 

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Phase I/II study of immunotherapy using autologous tumor lysate-pulsed dendritic cells in patients with metastatic renal cell carcinoma. Abstract Text:

Jung Han Kim,Yoon Lee,Yong-Soo Bae,Won Seog Kim,Kihyun Kim,Ho Yeong Im,Won Ki Kang,Keunchil Park,Han Yong Choi,Hyun Moo Lee,So-Young Baek,Hyunah Lee,Hyounmie Doh,Byong-Moon Kim,Chae Young Kim,Choonju Jeon,Chul Won Jung,Jung Han Kim,Yoon Lee,Yong-Soo Bae,Won Seog Kim,Kihyun Kim,Ho Yeong Im,Won Ki Kang,Keunchil Park,Han Yong Choi,Hyun Moo Lee,So-Young Baek,Hyunah Lee,Hyounmie Doh,Byong-Moon Kim,Chae Young Kim,ChoonJu Jeon,Chul Won Jung,Jung Han Kim,Yoon Lee,Yong-Soo Bae,Won Seog Kim,Kihyun Kim,Ho Yeong Im,Won Ki Kang,Keunchil Park,Han Yong Choi,Hyun Moo Lee,So-Young Baek,Hyunah Lee,Hyounmie Doh,Byong-Moon Kim,Chae Young Kim,ChoonJu Jeon,Chul Won Jung,

This phase I/II study was conducted to evaluate the feasibility, safety and efficacy of immunotherapy using tumor lysate (TL)-pulsed dendritic cells (DC) in patients with metastatic renal cell carcinoma (RCC). DC were generated by culturing peripheral blood mononuclear cells in the presence of GM-CSF and IL-4 and were pulsed with autologous TL and keyhole limpet hemocyanin (KLH). Maturation of DC was induced by a combined treatment of CD40 ligand, IFN and monocyte-conditioned medium. The patients were administered two cycles of TL-pulsed DCs vaccination, each of which comprised of four doses injected subcutaneously at biweekly intervals. Nine patients were included. The immunotherapy was well tolerated without severe side effects. One patient achieved an objective partial response (PR). Five patients showed stable disease (SD), and the remaining three had progressive disease (PD). With a median follow-up of 17.5 months, the median time to progression was 5.2 months and the median overall survival was 29 months. In the antigen-specific lymphocyte proliferation assay, eight patients showed a proliferative response, which tended to be stronger in patients with SD or PR than in patients with PD. The ELISPOT assay was performed in two patients and indicated that one patient with PR showed a much stronger response than another with PD. Our results suggest that TL-pulsed DC immunotherapy in combination with nephrectomy affect the natural course of RCC and are associated with clinical benefits for patients with metastatic diseases.

Phase I/II study of immunotherapy using autologous tumor lysate-pulsed dendritic cells in patients with metastatic renal cell carcinoma. Publishing Authors By Initials

JH Kim,Y Lee,YS Bae,WS Kim,K Kim,HY Im,WK Kang,K Park,HY Choi,HM Lee,SY Baek,H Lee,H Doh,BM Kim,CY Kim,C Jeon,CW Jung,JH Kim,Y Lee,YS Bae,WS Kim,K Kim,HY Im,WK Kang,K Park,HY Choi,HM Lee,SY Baek,H Lee,H Doh,BM Kim,CY Kim,C Jeon,CW Jung,JH Kim,Y Lee,YS Bae,WS Kim,K Kim,HY Im,WK Kang,K Park,HY Choi,HM Lee,SY Baek,H Lee,H Doh,BM Kim,CY Kim,C Jeon,CW Jung,

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Phase I/II study of immunotherapy using autologous tumor lysate-pulsed dendritic cells in patients with metastatic renal cell carcinoma. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical immunology (Orlando, Fla.)

VOLUME: 125

Page Numbers: 257-67

Journal Abbreviation: Clin. Immunol.

ISSN: 1521-6616

DAY: 3

MONTH: 10

YEAR: 2007

Phase I/II study of immunotherapy using autologous tumor lysate-pulsed dendritic cells in patients with metastatic renal cell carcinoma. Information

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LANGUAGE: eng

NlmUniqueID: 100883537

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AFFILIATION: Division of Hematology/Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Ilwon-Dong 50, Gangnam-Gu, Seoul, Korea.

Country: United States

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MEDLINETA: Clin Immunol

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