Phase I study of 5-azacytidine (NSC-102816) using 24-hour continuous infusion for 5 days.

Phase I study of 5-azacytidine (NSC-102816) using 24-hour continuous infusion for 5 days. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Phase I study of 5-azacytidine (NSC-102816) using 24-hour continuous infusion for 5 days. Abstract Text:

P L Lomen,L H Baker,G L Neil,M K Samson,

The biologic and antitumor activity of 5-azacytidine has been well demonstrated in the past. The drug at present is thought to be primarily cell cycle phase specific. This study was designed to eliminate undesirable side effects (mainly nausea and vomiting) occurring with a bolus dose and to confirm the recent findings of the relative stability of 5-azacytidine's solution with preserved biologic and antitumor activity. In the study we determined that a dose of 150 mg/m2/day given as a 120-hour continuous iv infusion and repeated at 28-day intervals produced safe, manageable, and reproducible toxicity. The drug was freshly prepared at 4-hour intervals. Eleven courses were administered to seven patients at this dose level and no patient experienced nausea or vomiting. Leukopenia was the major toxic effect. Antitumor activity was shown in one patient with colon cancer and another with American Burkitt's lymphoma.

Phase I study of 5-azacytidine (NSC-102816) using 24-hour continuous infusion for 5 days. Publishing Authors By Initials

PL Lomen,LH Baker,GL Neil,MK Samson,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: remission, spontaneous research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: remission, spontaneous research

PUBMED ID PMID:

MEDLINE DATE: 1975 Nov-Dec

Phase I study of 5-azacytidine (NSC-102816) using 24-hour continuous infusion for 5 days. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Cancer chemotherapy reports. Part 1

VOLUME: 59

Page Numbers: 1123-6

Journal Abbreviation:

ISSN: 0069-0112

DAY: 20

MONTH: 02

YEAR: 2008

Phase I study of 5-azacytidine (NSC-102816) using 24-hour continuous infusion for 5 days. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7607105

Phase I study of 5-azacytidine (NSC-102816) using 24-hour continuous infusion for 5 days. Keywords Mesh Terms:

KEYWORDS: Remission, Spontaneous

MESH TERMS: drug therapy

Chemical & Substance for Abstract: Phase I study of 5-azacytidine (NSC-102816) using 24-hour continuous infusion for 5 days. Information

Substance Name: Azacitidine

Registry Number: 320-67-2

Grant and Affiliation Information for Phase I study of 5-azacytidine (NSC-102816) using 24-hour continuous infusion for 5 days.

AFFILIATION:

Country: UNITED STATES

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Cancer Chemother Rep

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Phase I study of 5-azacytidine NSC-102816 using 24-hour continuous infusion for 5 days Related Publications

• Antimicrobial factors in human milk. Studies of concentration and transfer to the infant during the early stages of lactation.
• Arthroplasty of the knee joint; late results.
• Commentary on "should statins be given routinely before carotid endarterectomy?".
• Congenital multifocal osteomyelitis at 24 weeks' gestation.
• Genetic association and functional studies of major polymorphic variants of MGMT.
• Intermedin 17-47 does not function as a full intermedin antagonist within the central nervous system or pituitary.
• Intrathoracic meningocele.
• New taxa of Neosartorya and Aspergillus in Aspergillus section Fumigati.
• Not Available
• Percutaneous intraspinal navigation: feasibility study of a new and minimally invasive approach to the spinal cord and brain in cadavers.
• Phase I study of 5-azacytidine (NSC-102816) using 24-hour continuous infusion for 5 days.
• Postoperative angiography in carotid artery surgery.
• Postradiation soft tissue sarcoma of the shoulder: a case report.
• Prokineticin 2/Bv8 is expressed in Kupffer cells in liver and is down regulated in human hepatocellular carcinoma.
• Restriction of range and the predictive validity of the New Medical College Admission Test.
• Seronegative spondyloarthropathies and the eye.
• Sexual Reproduction as the Cause of Heat Resistance in the Food Spoilage Fungus Byssochlamys spectabilis (Anamorph Paecilomyces variotii).
• Some chemical properties of Manila tap water and their relation to corrosion of the distribution system.
• Spontaneous resolution of arteriovenous malformation without hemorrhage.
• Strangulation of the stomach and traumatic diaphragmatic hernia.
• The Protein Degradation Response of Saccharomyces cerevisiae to Classical DNA-Damaging Agents.
• The perfect storm: Torsades de Pointes in a child with leukemia.
• The subfascial approach to perforator dissection: a novel method for identification and harvest.
• Transcriptional Networks in S. cerevisiae Linked to an Accumulation of Base Excision Repair Intermediates.
• Treatment of traumatic arterial vasospasm with intraarterial papaverine infusion.
• Tuberculosis survey in the largest mental hospitals of the Province of Quebec; measures for the control and the specific prevention of this disease.
• Why do picture naming latencies increase with age: general slowing, greater sensitivity to interference, or task-specific deficits?
• [A new case of acute pancreatitis treated and stabilized by means of anti-enzymes. Discussion of the therapy.]
• [Not Available.]
• [South African Nurses' Association. Congress, 1972. Nursing research]