Pharmacotherapy of lower limb diabetic ulcers.

Pharmacotherapy of lower limb diabetic ulcers. Research Abstract Details 

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Pharmacotherapy of lower limb diabetic ulcers. Abstract Text:

OBJECTIVE: To discuss the pathophysiology, microbiology, and pharmacotherapy of lower extremity (LE) diabetic ulcers. DATA SOURCES: A MEDLINE search from 1966 to April 1999 was conducted. The search was limited to humans and English-language journals. Key search words included "diabetic ulcer," "fluoroquinolones," "beta-lactam," "hyperbaric oxygen," "diabetes mellitus," "diabetic foot," and "growth factor." STUDY SELECTION: Randomized and nonrandomized studies were selected for review. Results of randomized, placebo-controlled studies were emphasized more than nonrandomized results. DATA SYNTHESIS: LE ulcers are a common cause of hospitalization, and cause significant morbidity and mortality. Staphylococcus aureus is the most common pathogen in non-limb-threatening infections; Gram-negative bacteria and anaerobes are most prevalent in limb-threatening and life-threatening infections. Oral antibiotic therapy may be used in non-limb-threatening infections, if adequate response is achieved in 24-48 hours; otherwise, intravenous antibiotics should be started. Intravenous antibiotics should be the initial therapy for limb-threatening or life- threatening ulcers. Antimicrobial therapy of at least 10-14 days has been effective in treating LE ulcers in the absence of osteomyelitis. Growth factors offer another treatment alternative, although only becaplermin is currently approved for diabetic ulcers. CONCLUSION: Antibiotic therapy has been effective for the treatment of LE diabetic ulcers. However, further studies are required to identify optimal antibiotics and dosage regimens. Growth factors may have a role but additional research is needed to determine when best to initiate this therapy.

Pharmacotherapy of lower limb diabetic ulcers. Publishing Authors By Initials

For similar diagnosis: prognosis: treatment outcome research abstracts see: diagnosis: prognosis: treatment outcome research

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Pharmacotherapy of lower limb diabetic ulcers. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of the American Geriatrics Society

VOLUME: 48

Page Numbers: 822-8

Journal Abbreviation: J Am Geriatr Soc

ISSN: 0002-8614

DAY: 10

MONTH: Jul

YEAR: 2000

Pharmacotherapy of lower limb diabetic ulcers. Information

Number of References: 68

LANGUAGE: eng

NlmUniqueID: 7503062

Pharmacotherapy of lower limb diabetic ulcers. Keywords Mesh Terms:

KEYWORDS: Treatment Outcome

MESH TERMS: drug therapy

Chemical & Substance for Abstract: Pharmacotherapy of lower limb diabetic ulcers. Information

Substance Name: platelet-derived growth factor BB

Registry Number: 0

Grant and Affiliation Information for Pharmacotherapy of lower limb diabetic ulcers.

AFFILIATION: College of Pharmacy, The Ohio State University and Children's Hospital, Columbus 43210, USA.

Country: UNITED STATES

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MEDLINETA: J Am Geriatr Soc

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