Pharmacological Properties of SD-282 - An alpha-Isoform Selective Inhibitor for p38 MAP Kinase.

Pharmacological Properties of SD-282 - An alpha-Isoform Selective Inhibitor for p38 MAP Kinase. Research Abstract Details 

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Pharmacological Properties of SD-282 - An alpha-Isoform Selective Inhibitor for p38 MAP Kinase. Abstract Text:

Bruce Koppelman,Heather K Webb,Satyanarayana Medicherla,Ramona Almirez,Ying Feng,Jose Carlos Chavez,Cheng Ping Mao,Aaron Nguyen,Yu-Wang Liu,Ann M Kapoun,Gladys Muiru,Yuanying Anne Huang,Sundeep Dugar,Babu J Mavunkel,Don W Lim,Sarvajit Chakravarty,Gregory Luedtke,Andrew A Protter,Linda S Higgins,Bruce Koppelman,Heather K Webb,Satyanarayana Medicherla,Ramona Almirez,Ying Feng,Jose Carlos Chavez,Cheng Ping Mao,Aaron Nguyen,Yu-Wang Liu,Ann M Kapoun,Gladys Muiru,Yuanying Anne Huang,Sundeep Dugar,Babu J Mavunkel,Don W Lim,Sarvajit Chakravarty,Gregory Luedtke,Andrew A Protter,Linda S Higgins,

The effects of small-molecule p38 inhibitors in numerous models of different disease states have been published, including those of SD-282, an indole-5-carboxamide inhibitor. The aim of the present study was to evaluate the pharmacological activity of SD-282 on cytokine production in vitro as well as in 2 in vivo models of inflammation in order to illuminate the role of this particular inhibitor in diverse disease states. The results presented here provide further characterization of SD-282 and provide a context in which to interpret the activity of this p38 inhibitor in models of arthritis, pain, myocardial injury, sepsis and asthma; all of which have an inflammatory component. SD-282 represents a valuable tool to elucidate the role of p38 MAP kinase in multiple models of inflammation. Copyright (c) 2008 S. Karger AG, Basel.

Pharmacological Properties of SD-282 - An alpha-Isoform Selective Inhibitor for p38 MAP Kinase. Publishing Authors By Initials

B Koppelman,HK Webb,S Medicherla,R Almirez,Y Feng,JC Chavez,CP Mao,A Nguyen,YW Liu,AM Kapoun,G Muiru,YA Huang,S Dugar,BJ Mavunkel,DW Lim,S Chakravarty,G Luedtke,AA Protter,LS Higgins,B Koppelman,HK Webb,S Medicherla,R Almirez,Y Feng,JC Chavez,CP Mao,A Nguyen,YW Liu,AM Kapoun,G Muiru,YA Huang,S Dugar,BJ Mavunkel,DW Lim,S Chakravarty,G Luedtke,AA Protter,LS Higgins,

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Pharmacological Properties of SD-282 - An alpha-Isoform Selective Inhibitor for p38 MAP Kinase. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Pharmacology

VOLUME: 81

Page Numbers: 204-20

Journal Abbreviation: Pharmacology

ISSN: 1423-0313

DAY: 7

MONTH: 01

YEAR: 2008

Pharmacological Properties of SD-282 - An alpha-Isoform Selective Inhibitor for p38 MAP Kinase. Information

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LANGUAGE: eng

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AFFILIATION: Scios, Inc., Fremont, Calif., USA.

Country: Switzerland

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MEDLINETA: Pharmacology

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