Pharmacokinetics of intravenous midazolam during epidural anaesthesia.

Pharmacokinetics of intravenous midazolam during epidural anaesthesia. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Pharmacokinetics of intravenous midazolam during epidural anaesthesia. Abstract Text:

Midazolam concentration curves versus time were analysed in 10 otherwise healthy patients (ASA I-II) with inferior limb pathologies. The benzodiazepine was used as an adjuvant agent to epidural anaesthesia in view of its lower residual effect compared with other intravenous benzodiazepines. Midazolam pharmacokinetics in these patients fitted an open two-compartment model. The plasma levels versus time corresponded to a biexponential process with a very rapid distribution phase (t1/2a = 5.7 +/- 2.4 min) and an elimination phase (t1/2 beta = 66 +/- 37 min). Mean values for distribution volumes in the central compartment and extrapolated values were Vc = 0.12 +/- 0.04 l/kg and V beta = 1.28 +/- 0.92 l/kg. This kinetic behaviour explains the rapid but short duration of midazolam action. The induction time, estimated from the start of hypnosis (eye closure), was from 60 to 120 s with i.v. injection. The duration of action for the dose administered was from 15 to 60 min, with plasma levels below 90 ng/ml upon eye opening.

Pharmacokinetics of intravenous midazolam during epidural anaesthesia. Publishing Authors By Initials

For similar persons: age groups: adult: middle aged research abstracts see: persons: age groups: adult: middle aged research

PUBMED ID PMID:

MEDLINE DATE:

Pharmacokinetics of intravenous midazolam during epidural anaesthesia. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of clinical pharmacy and therapeutics

VOLUME: 16

Page Numbers: 209-14

Journal Abbreviation: J Clin Pharm Ther

ISSN: 0269-4727

DAY: 28

MONTH: Jun

YEAR: 1991

Pharmacokinetics of intravenous midazolam during epidural anaesthesia. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8704308

Pharmacokinetics of intravenous midazolam during epidural anaesthesia. Keywords Mesh Terms:

KEYWORDS: Middle Aged

MESH TERMS: pharmacokinetics

Chemical & Substance for Abstract: Pharmacokinetics of intravenous midazolam during epidural anaesthesia. Information

Substance Name: Midazolam

Registry Number: 59467-70-8

Grant and Affiliation Information for Pharmacokinetics of intravenous midazolam during epidural anaesthesia.

AFFILIATION: Department of Pharmaceutical Services, Lluis Alcanyis Hospital, Xàtiva, Spain.

Country: ENGLAND

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Clin Pharm Ther

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Pharmacokinetics of intravenous midazolam during epidural anaesthesia Related Publications

• A novel method for determining the ventilation threshold and respiratory compensation point: 2016: board #86 may 31 2:00 PM - 3:30 PM.
• About the presence of hemosiderin in the hippocampus of Alzheimer patients.
• Cardiovascular Health Parameter Changes in Overweight Adolescents Participating in One vs Two Semesters of Physical Education: 586: May 30 2:15 PM 2:30 PM.
• Changes in body composition and physical activity of adolescents participating in physical education: 585: may 30 2:00 PM 2:15 PM.
• Display of ordinary transmission holograms with a white light source.
• Distinct phosphatases mediate the deactivation of the DNA damage checkpoint kinase rad53.
• Early parathyroid MIBI SPECT imaging in the diagnosis of persistent hyperparathyroidism.
• Fixation-free methods in bleached reflection holography.
• Heparinized solution vs. saline solution in the maintenance of arterial catheters: a double blind randomized clinical trial.
• Pharmacokinetics of intravenous midazolam during epidural anaesthesia.
• Platelet imipramine binding in endogenous depressed patients and controls: relationship to platelet MAO and 5HT uptake during successful imipramine treatment.
• Pneumonia: criteria for patient instability on hospital discharge.
• Prophylaxis and treatment of chronic synovitis in haemophilia patients with inhibitors.
• SCIPE - a simple control interface protocol for experimenters.
• Short-term effects of changes in water management on the limnological characteristics and zooplankton of a eutrophic Mediterranean coastal lagoon (NE Iberian Peninsula).
• The life cycle of Stephanoprora aylacostoma n.sp. (Digenea: Echinostomatidae), parasite of the threatened snail Aylacostoma chloroticum (Prosobranchia, Thiaridae), in Argentina.
• Time course of rod influences on hue perception.
• Visual recognition memory in normal adults and patients with unilateral vascular lesions.
• [Ants in a hospital environment and its importance as vector of bacteria.]
• [Carotid thromboendarterectomy in the elderly patient: clinical characteristics in operated patients and short and middle term results.]
• [Description of the accounting system of the health services of the São Paulo region, Brazil]
• [Frequency of pregnant HBsAg carriers in a Brazilian community]
• [Interobserver correlation in the interpretation of 99mTc-sestamibi SPECT in reperfused acute myocardial infarction.]
• [Isolation of a strain from the Bataviae pathogenic complex in patient vaccinated against copenhageni, canicola and mozdok]
• [Lung cancer in Spain: the current situation. 2008 SESPAS Report.]
• [Music versus diazepam to reduce preoperative anxiety: a randomized controlled clinical trial]
• [Spinal dural arteriovenous fístula: surgical or endovascular treatment?]