Pharmacokinetics of beta-receptor-blocking agents in relation to their anti-hypertensive effect.

Pharmacokinetics of beta-receptor-blocking agents in relation to their anti-hypertensive effect. Research Abstract Details 

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Pharmacokinetics of beta-receptor-blocking agents in relation to their anti-hypertensive effect. Abstract Text:

R Gugler,G Bodem,H J Dengler,

1. Beta-Recptor-blocking drugs are rapidly and completely absorbed after oral administration. Systemic availability is nevertheless incomplete for propranolol, alprenolol and oxprenolol, owing to "first-pass' extraction by the liver. 2. Plasma half-life is between 2 and 4 h, except for sotalol (10-12 h). Plasma elimination of propranolol is reduced with decreased liver blood flow observed in congestive heart failure or during chronic propranolol therapy itself. 3. beta-Receptor blockade is usually achieved in these concentration ranges: propranolol and alprenolol, 50-100 ng/ml; oxprenolol, 500-1000 ng/ml; pindolol, 10-30 ng/ml; sotalol, 2-6 microng/ml. Higher concentrations are often found with high doses administered to hypertensive patients.

Pharmacokinetics of beta-receptor-blocking agents in relation to their anti-hypertensive effect. Publishing Authors By Initials

R Gugler,G Bodem,HJ Dengler,

For similar digestive system: liver research abstracts see: digestive system: liver research

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Pharmacokinetics of beta-receptor-blocking agents in relation to their anti-hypertensive effect. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical science and molecular medicine. Supplemen

VOLUME: 3

Page Numbers: 473s-475s

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ISSN: 0144-4107

DAY: 12

MONTH: Dec

YEAR: 1976

Pharmacokinetics of beta-receptor-blocking agents in relation to their anti-hypertensive effect. Information

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LANGUAGE: eng

NlmUniqueID: 7907311

Pharmacokinetics of beta-receptor-blocking agents in relation to their anti-hypertensive effect. Keywords Mesh Terms:

KEYWORDS: Liver

MESH TERMS: metabolism

Chemical & Substance for Abstract: Pharmacokinetics of beta-receptor-blocking agents in relation to their anti-hypertensive effect. Information

Substance Name: Adrenergic beta-Antagonists

Registry Number: 0

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Country: ENGLAND

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MEDLINETA: Clin Sci Mol Med Suppl

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