[Pharmacokinetic study of ketoprofen in rat by blood microdialysis technique]

[Pharmacokinetic study of ketoprofen in rat by blood microdialysis technique] Research Abstract Details 

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[Pharmacokinetic study of ketoprofen in rat by blood microdialysis technique] Abstract Text:

Hai-Bing He,Xing Tang,Fu-De Cui,Hai-Bing He,Xing Tang,Fu-De Cui,

AIM: To investigate the in vitro recovery and influencing factors of ketoprofen in microdialysis probe, and study the pharmacokinetic of unbound ketoprofen in rat after iv administration. METHODS: The recovery of ketoprofen was detected by a concentration difference method. After microdialysis probe was inserted into the jugular vein of male Wistar rats, the probe was infused with various concentrations perfusate. The in vivo recovery and the pharmacokinetics of unbound ketoprofen in rat were investigated. Dialysate samples were determined by HPLC. RESULTS: The recovery detected by gain was as the same as that by loss; the recovery was independent of the drug concentration surrounding the probe. The in vitro recovery was 28.75% by concentration difference method and the in vivo recovery was (40.3 +/- 2.7) % by retrodialysis method. After i.v. administration of ketoprofen in rat, T 1/2, AUC and CL of unbound ketoprofen were (181 +/- 16) min, (112 +/- 27) microg x min x mL(-1) and (0.22 +/- 0.05) L x min(-1), respectively. CONCLUSION: Microdialysis sampling can be used for the pharmacokinetic study of unbound ketoprofen in rat.

[Pharmacokinetic study of ketoprofen in rat by blood microdialysis technique] Publishing Authors By Initials

HB He,X Tang,FD Cui,HB He,X Tang,FD Cui,

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[Pharmacokinetic study of ketoprofen in rat by blood microdialysis technique] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Yao xue xue bao = Acta pharmaceutica Sinica

VOLUME: 41

Page Numbers: 452-6

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ISSN: 0513-4870

DAY: 19

MONTH: May

YEAR: 2006

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LANGUAGE: chi

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AFFILIATION: School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.

Country: China

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MEDLINETA: Yao Xue Xue Bao

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