Pharmacokinetic-rate images of indocyanine green for breast tumors using near-infrared optical methods.

Pharmacokinetic-rate images of indocyanine green for breast tumors using near-infrared optical methods. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Pharmacokinetic-rate images of indocyanine green for breast tumors using near-infrared optical methods. Abstract Text:

Burak Alacam,Birsen Yazici,Xavier Intes,Shoko Nioka,Britton Chance,Burak Alacam,Birsen Yazici,Xavier Intes,Shoko Nioka,Britton Chance,

In this paper, we develop a method of forming pharmacokinetic-rate images of indocyanine green (ICG) and apply our method to in vivo data obtained from three patients with breast tumors. To form pharmacokinetic-rate images, we first obtain a sequence of ICG concentration images using the differential diffuse optical tomography technique. We next employ a two-compartment model composed of plasma, and extracellular-extravascular space (EES), and estimate the pharmacokinetic rates and concentrations in each compartment using the extended Kalman filtering framework. The pharmacokinetic-rate images of the three patient show that the rates from the tumor region and outside the tumor region are statistically different. Additionally, the ICG concentrations in plasma, and the EES compartments are higher around the tumor region agreeing with the hypothesis that around the tumor region ICG may act as a diffusible extravascular flow in compromised capillary of cancer vessels. Our study indicates that the pharmacokinetic-rate images may provide superior information than single set of pharmacokinetic rates estimated from the entire breast tissue for breast cancer diagnosis.

Pharmacokinetic-rate images of indocyanine green for breast tumors using near-infrared optical methods. Publishing Authors By Initials

B Alacam,B Yazici,X Intes,S Nioka,B Chance,B Alacam,B Yazici,X Intes,S Nioka,B Chance,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Pharmacokinetic-rate images of indocyanine green for breast tumors using near-infrared optical methods. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Physics in medicine and biology

VOLUME: 53

Page Numbers: 837-59

Journal Abbreviation:

ISSN: 0031-9155

DAY: 15

MONTH: 01

YEAR: 2008

Pharmacokinetic-rate images of indocyanine green for breast tumors using near-infrared optical methods. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 401220

Pharmacokinetic-rate images of indocyanine green for breast tumors using near-infrared optical methods. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Pharmacokinetic-rate images of indocyanine green for breast tumors using near-infrared optical methods. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Pharmacokinetic-rate images of indocyanine green for breast tumors using near-infrared optical methods.

AFFILIATION: Department of Electrical, Computer, and Systems Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Phys Med Biol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Pharmacokinetic-rate images of indocyanine green for breast tumors using near-infrared optical methods Related Publications

• A determination of H2O2 release by the treatment of human blood polymorphonuclear leukocytes with myristate.
• Analysis of ICG Pharmacokinetics in Cancerous Tumors using NIR Optical Methods.
• Beamline X29: a novel undulator source for X-ray crystallography.
• Complementary structural mass spectrometry techniques reveal local dynamics in functionally important regions of a metastable serpin.
• Early printing of medical books and some of the printers who printed them.
• Effects of exercise frequency on artery stiffness in elderly women: 882: june 1 2:00 PM - 2:15 PM.
• Extended kalman filtering for the modeling and analysis of ICG pharmacokinetics in cancerous tumors using NIR optical methods.
• Fluorescence spectroscopy and imaging of myocardial apoptosis.
• Impaired Skeletal Muscle Blood Flow, Mitochondrial Function and Exercise Capacity in Type II Diabetes with PAD: A Simultaneous MRS and 31P-MRS Study: 2347: Board #26 June 1 2:00 PM -3:30 PM.
• Modeling of protein binary complexes using structural mass spectrometry data.
• Near-infrared spectroscopy/imaging for monitoring muscle oxygenation and oxidative metabolism in healthy and diseased humans.
• Pharmacokinetic-rate images of indocyanine green for breast tumors using near-infrared optical methods.
• Simulation of Mb/Hb in NIRS and oxygen gradient in the human and canine skeletal muscles using H-NMR and NIRS.
• Simultaneous fluorometry and phosphorometry of Langendorff perfused rat heart: ex vivo animal studies.
• Some aspects of radio-therapy.
• Some characteristics of hydrogen- and alkylhydroperoxides metabolizing systems in cardiac tissue.
• The Beamline X28C of the Center for Synchrotron Biosciences: a national resource for biomolecular structure and dynamics experiments using synchrotron footprinting.
• The composition of catalase-peroxide complexes.
• The enzyme-substrate compounds of horseradish peroxidase and peroxides; kinetics of formation and decomposition of the primary and secondary complexes.
• The measurement of the structure and behaviour of therapeutic groups.
• The oxidation of ferrocytochrome-c by peroxidase and peroxides.
• The primary and secondary compounds of catalase and methyl or ethyl hydrogen peroxide; kinetics and activity.
• The primary and secondary compounds of catalase and methyl or ethyl hydrogen peroxide; reactions in concentrated alkyl hydrogen peroxide solutions.
• The primary and secondary compounds of catalase and methyl or ethyl hydrogen peroxide; reactions with hydrogen peroxide.
• The primary and secondary compounds of catalase and methyl or ethyl hydrogen peroxide; spectra.
• The properties of the enzyme-substrate compounds of peroxidase and peroxides; the spectra of the primary and secondary complexes.
• The reaction of catalase and cyanide.
• Three-dimensional structure of cofilin bound to monomeric actin derived by structural mass spectrometry data.
• Visualizing Arp2/3 complex activation mediated by binding of ATP and WASp using structural mass spectrometry.
• Where from Peckham?