Pharmacokinetic parameters: which are necessary to define a drug substance?

Pharmacokinetic parameters: which are necessary to define a drug substance? Research Abstract Details 

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Pharmacokinetic parameters: which are necessary to define a drug substance? Abstract Text:

L Z Benet,

Pharmacokinetics describe what the body does to the drug, as opposed to pharmacodynamics which describe what the drug does to the body. Pharmacokinetic information is required to optimize the pharmacodynamic response. The primary pharmacokinetic disposition parameter is clearance. Knowledge of this value and its major constituent parts, i.e. fractional renal and hepatic elimination, allows the clinician to prescribe the correct dosage regimen to obtain a mean therapeutic concentration and to predict the effects of various disease states. The other primary disposition parameter, volume of distribution at steady-state, may also vary with changes in physiologic and pathologic conditions. Both clearance and volume of distribution as well as the correlation of concentration measurements with pharmacodynamics would be expected to vary with changes in plasma protein binding. Although plasma concentration measurements are usually easiest to perform, interpretation of parameters in physiologic terms requires blood concentration, so the blood/plasma partition parameter should be determined. Although half-life is a composite parameter reflecting changes in both clearance and volume of distribution, it is a value which defines the maximum and minimum blood concentrations obtained for a particular dosage regimen, important quantities in defining the pharmacodynamic response. The major pharmacokinetic input parameter is the extent of availability as a function of route of administration. This parameter, as well as all of the disposition parameters discussed above, may be determined without designating a particular pharmacokinetic model. Only the rate of availability requires a model, although peak time and peak concentration are reasonable noncompartmental substitutes.

Pharmacokinetic parameters: which are necessary to define a drug substance? Publishing Authors By Initials

LZ Benet,

For similar pharmaceutical preparations research abstracts see: pharmaceutical preparations research

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Pharmacokinetic parameters: which are necessary to define a drug substance? Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: European journal of respiratory diseases. Suppleme

VOLUME: 134

Page Numbers: 45-61

Journal Abbreviation:

ISSN: 0106-4347

DAY: 21

MONTH: 02

YEAR: 1984

Pharmacokinetic parameters: which are necessary to define a drug substance? Information

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LANGUAGE: eng

NlmUniqueID: 8010618

Pharmacokinetic parameters: which are necessary to define a drug substance? Keywords Mesh Terms:

KEYWORDS: Pharmaceutical Preparations

MESH TERMS: metabolism

Chemical & Substance for Abstract: Pharmacokinetic parameters: which are necessary to define a drug substance? Information

Substance Name: Pharmaceutical Preparations

Registry Number: 0

Grant and Affiliation Information for Pharmacokinetic parameters: which are necessary to define a drug substance?

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Country: DENMARK

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MEDLINETA: Eur J Respir Dis Suppl

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