Pharmacogenomics of cancer chemopreventive isothiocyanate compound sulforaphane in the intestinal polyps of ApcMin/+ mice.

Pharmacogenomics of cancer chemopreventive isothiocyanate compound sulforaphane in the intestinal polyps of ApcMin/+ mice. Research Abstract Details 

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Pharmacogenomics of cancer chemopreventive isothiocyanate compound sulforaphane in the intestinal polyps of ApcMin/+ mice. Abstract Text:

Tin Oo Khor,Rong Hu,Guoxiang Shen,Woo-Sik Jeong,Vidya Hebbar,Chi Chen,Changjiang Xu,Sujit Nair,Bandaru Reddy,Kiran Chada,Ah-Ng Tony Kong,

Sulforaphane (SFN) is an isothiocyanate that is present in widely consumed vegetables. Previous studies have shown that SFN is effective in preventing carcinogenesis induced by carcinogens in rodents. Recently it was found that SFN could also suppress the growth of intestinal polyps in the ApcMin/+ mouse. In the present study, the acute effect of SFN on the gene expression profile in small intestinal polyps of ApcMin/+ mice using Affymetrix microarray was performed. SFN is a strong inducer for phase II drug metabolizing enzymes, which is believed to contribute to its chemopreventive properties. However, the results show that genes involved in apoptosis, cell growth and maintenance rather than the predicted phase II genes were modulated. The proapoptotic genes including MBD4, TNFR-7 and TNF (ligand)-11 were up-regulated while pro-survival genes including cyclin-D2, integrin-beta1 and Wnt-9A were down-regulated. Interestingly, two genes potentially involved in colorectal carcinogenesis, 15-LOX and COX-2 were found to be increased and decreased, respectively. In conclusion, the results show, for the first time, that chemopreventive agents such as SFN regulate different set of genes involving apoptosis, cell growth/maintenance and inflammation in the small intestinal polyps of ApcMin/+ mice, which could contribute to the overall chemopreventive pharmacological effects.

Pharmacogenomics of cancer chemopreventive isothiocyanate compound sulforaphane in the intestinal polyps of ApcMin/+ mice. Publishing Authors By Initials

TO Khor,R Hu,G Shen,WS Jeong,V Hebbar,C Chen,C Xu,S Nair,B Reddy,K Chada,AN Kong,

For similar organic chemicals: cyanates: thiocyanates research abstracts see: organic chemicals: cyanates: thiocyanates research

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Pharmacogenomics of cancer chemopreventive isothiocyanate compound sulforaphane in the intestinal polyps of ApcMin/+ mice. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Biopharmaceutics & drug disposition

VOLUME: 27

Page Numbers: 407-20

Journal Abbreviation:

ISSN: 0142-2782

DAY: 3

MONTH: Dec

YEAR: 2006

Pharmacogenomics of cancer chemopreventive isothiocyanate compound sulforaphane in the intestinal polyps of ApcMin/+ mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7911226

Pharmacogenomics of cancer chemopreventive isothiocyanate compound sulforaphane in the intestinal polyps of ApcMin/+ mice. Keywords Mesh Terms:

KEYWORDS: Thiocyanates

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Pharmacogenomics of cancer chemopreventive isothiocyanate compound sulforaphane in the intestinal polyps of ApcMin/+ mice. Information

Substance Name: Cyclooxygenase 2

Registry Number: EC 1.14.99.1

Grant and Affiliation Information for Pharmacogenomics of cancer chemopreventive isothiocyanate compound sulforaphane in the intestinal polyps of ApcMin/+ mice.

AFFILIATION: Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.

Country: England

AGENCY: United States NCI

GRANT: CA073674

ACRONYM: CA

MEDLINETA: Biopharm Drug Dispos

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