Phagocyte function and cell-mediated immunity in systemic lupus erythematosus.

Phagocyte function and cell-mediated immunity in systemic lupus erythematosus. Research Abstract Details 

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Phagocyte function and cell-mediated immunity in systemic lupus erythematosus. Abstract Text:

Lymphocyte, granulocyte, and macrophage function were studied simultaneously in 26 untreated patients with systemic lupus erythematosus (SLE) and 26 matched controls. The overall cellular response, as assessed in vivo by skin tests and sensitization to dinitrochlorobenzene, was diminished in the SLE group. Although T cells were reduced in number in patients with SLE, their function appeared unimpaired, as shown by normal lymphocyte transformation to phytohemagglutinin and bacterial and fungal antigens. The depressed cutaneous reactivity observed in vivo was explained by the finding of major deficits in the efferent limb of cellular immunity. Initial rate of phagocytosis of both polymorphonuclear neutrophils and macrophages was significantly reduced in patients with SLE as compared with normal persons. Because of cell interaction, the presence of an intrinsic macrophage defect in SLE may contribute to the alleged T- and B-cell dysfunction in that disease.

Phagocyte function and cell-mediated immunity in systemic lupus erythematosus. Publishing Authors By Initials

For similar cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes research abstracts see: cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes research

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Phagocyte function and cell-mediated immunity in systemic lupus erythematosus. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Archives of dermatology

VOLUME: 113

Page Numbers: 147-54

Journal Abbreviation: Arch Dermatol

ISSN: 0003-987X

DAY: 17

MONTH: Feb

YEAR: 1977

Phagocyte function and cell-mediated immunity in systemic lupus erythematosus. Information

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LANGUAGE: eng

NlmUniqueID: 372433

Phagocyte function and cell-mediated immunity in systemic lupus erythematosus. Keywords Mesh Terms:

KEYWORDS: T-Lymphocytes

MESH TERMS: immunology

Chemical & Substance for Abstract: Phagocyte function and cell-mediated immunity in systemic lupus erythematosus. Information

Substance Name: Dinitrochlorobenzene

Registry Number: 97-00-7

Grant and Affiliation Information for Phagocyte function and cell-mediated immunity in systemic lupus erythematosus.

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Country: UNITED STATES

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MEDLINETA: Arch Dermatol

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