pH-sensitive vesicles containing a lipidic beta-amino acid with two hydrophobic chains.

pH-sensitive vesicles containing a lipidic beta-amino acid with two hydrophobic chains. Research Abstract Details 

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pH-sensitive vesicles containing a lipidic beta-amino acid with two hydrophobic chains. Abstract Text:

Stefania Capone,Peter Walde,Dieter Seebach,Takashi Ishikawa,Romualdo Caputo,Stefania Capone,Peter Walde,Dieter Seebach,Takashi Ishikawa,Romualdo Caputo,

The lipidic beta-amino acid 2-(aminomethyl)-2-pentadecylheptadecanoic acid (1) was synthesized via the alkylation of the C(alpha)-atom of fully protected beta-alanine. Mixed large unilamellar vesicles with a diameter between 100 and 200 nm containing POPC (1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine) and 1 at a molar ratio of 9 : 1 were prepared and found to have a surface charge which is dependent on pH. At slightly acidic pH, the vesicles were positively charged, and at alkaline pH negatively charged. Dynamic light scattering, zeta potential, and cryo-transmission electron-microscopy measurements indicated that the mixed vesicles fused at pH 4-5 with negatively charged mixed vesicles composed of POPC and POPG (9.8 : 1, molar ratio), POPG being 1-palmitoyl-2-oleoyl-sn-glycero-3-[phospho-rac-(1-glycerol)].

pH-sensitive vesicles containing a lipidic beta-amino acid with two hydrophobic chains. Publishing Authors By Initials

S Capone,P Walde,D Seebach,T Ishikawa,R Caputo,S Capone,P Walde,D Seebach,T Ishikawa,R Caputo,

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pH-sensitive vesicles containing a lipidic beta-amino acid with two hydrophobic chains. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Chemistry & biodiversity

VOLUME: 5

Page Numbers: 16-30

Journal Abbreviation: Chem. Biodivers.

ISSN: 1612-1880

DAY: 30

MONTH: Jan

YEAR: 2008

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LANGUAGE: eng

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AFFILIATION: Laboratorium für Organische Chemie, Departement Chemie und Angewandte Biowissenschaften, ETH-Zürich, Wolfgang-Pauli-Strasse 10, CH-8093 Zürich.

Country: Switzerland

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MEDLINETA: Chem Biodivers

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