PET positive generalized lymphadenopathy and splenomegaly following interferon-alfa-2b adjuvant therapy for melanoma.

PET positive generalized lymphadenopathy and splenomegaly following interferon-alfa-2b adjuvant therapy for melanoma. Research Abstract Details 

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PET positive generalized lymphadenopathy and splenomegaly following interferon-alfa-2b adjuvant therapy for melanoma. Abstract Text:

Lawrence A Cone,Adam Brochert,Karl Schulz,Richard A Stone,Asma Kazi,David Greene,Lawrence A Cone,Adam Brochert,Karl Schulz,Richard A Stone,Asma Kazi,David Greene,

Interferon-alfa (IFN-alpha) is used in patients with various inflammatory and neoplastic disorders. We recently encountered fluorodeoxyglucose (FDG) uptake in generalized lymphadenopathy, splenomegaly, and the marrow in a patient receiving high dose interferon-alpha-2b (IFN-alpha) as adjuvant therapy for the treatment of malignant melanoma. Biopsy of an enlarged hypermetabolic axillary lymph node revealed only a reactive node. Discontinuation of IFN-alpha caused regression of splenomegaly and lymphadenopathy within 3 months.A marrow "hyperstimulation" pattern that can include the spleen is a well-recognized phenomenon on (fluorodeoxyglucose) FDG positron emission tomography/computed tomography (PET/CT) scans in patients receiving chemotherapeutic agents like interferon, though classically due to colony stimulating factors, but does not generally include lymphadenopathy. This case, which likely reflects an interferon-induced pseudolymphoma, highlights the importance of a drug history and clinical correlation for the proper interpretation of FDG PET/CT scans.

PET positive generalized lymphadenopathy and splenomegaly following interferon-alfa-2b adjuvant therapy for melanoma. Publishing Authors By Initials

LA Cone,A Brochert,K Schulz,RA Stone,A Kazi,D Greene,LA Cone,A Brochert,K Schulz,RA Stone,A Kazi,D Greene,

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PET positive generalized lymphadenopathy and splenomegaly following interferon-alfa-2b adjuvant therapy for melanoma. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical nuclear medicine

VOLUME: 32

Page Numbers: 793-6

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ISSN: 0363-9762

DAY: 21

MONTH: Oct

YEAR: 2007

PET positive generalized lymphadenopathy and splenomegaly following interferon-alfa-2b adjuvant therapy for melanoma. Information

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LANGUAGE: eng

NlmUniqueID: 7611109

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Grant and Affiliation Information for PET positive generalized lymphadenopathy and splenomegaly following interferon-alfa-2b adjuvant therapy for melanoma.

AFFILIATION: Department of Medicine, Eisenhower Medical Center, Rancho Mirage, CA 92270, USA.

Country: United States

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MEDLINETA: Clin Nucl Med

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