Pervasive combinatorial modification of histone H3 in human cells.

Pervasive combinatorial modification of histone H3 in human cells. Research Abstract Details 

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Pervasive combinatorial modification of histone H3 in human cells. Abstract Text:

We developed a platform using hydrophilic interaction chromatography and high-resolution tandem mass spectrometry (MS) for analyses of histone H3 that allows comprehensive characterization of 'histone codes' at the molecular level. We identified over 150 differentially modified forms of histone H3.2 in asynchronously grown and butyrate-treated HeLa cells, revealing pervasive combinatorial modification previously unaccounted for by other techniques and providing a clarified estimate of the molecular diversity of histone H3 in mammals.

Pervasive combinatorial modification of histone H3 in human cells. Publishing Authors By Initials

For similar genetic processes: gene expression regulation: protein modification, translational: protein processing, post-translational research abstracts see: genetic processes: gene expression regulation: protein modification, translational: protein processing, post-translational research

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Pervasive combinatorial modification of histone H3 in human cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Nature methods

VOLUME: 4

Page Numbers: 487-9

Journal Abbreviation: Nat. Methods

ISSN: 1548-7091

DAY: 21

MONTH: 05

YEAR: 2007

Pervasive combinatorial modification of histone H3 in human cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101215604

Pervasive combinatorial modification of histone H3 in human cells. Keywords Mesh Terms:

KEYWORDS: Protein Processing, Post-Translational

MESH TERMS: metabolism

Chemical & Substance for Abstract: Pervasive combinatorial modification of histone H3 in human cells. Information

Substance Name: Histones

Registry Number: 0

Grant and Affiliation Information for Pervasive combinatorial modification of histone H3 in human cells.

AFFILIATION: Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM 067193

ACRONYM: GM

MEDLINETA: Nat Methods

REFSOURCE: Nat Methods. 2007 Jun;4(6):480-1

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