Perturbations of natural killer cell regulatory functions in respiratory allergic diseases.

Perturbations of natural killer cell regulatory functions in respiratory allergic diseases. Research Abstract Details 

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Perturbations of natural killer cell regulatory functions in respiratory allergic diseases. Abstract Text:

Francesca Scordamaglia,Mirna Balsamo,Antonio Scordamaglia,Alessandro Moretta,Maria Cristina Mingari,Giorgio Walter Canonica,Lorenzo Moretta,Massimo Vitale,

BACKGROUND: Allergic diseases are characterized by abnormal responses to allergens favored by an inappropriate regulation of the T(H)1-T(H)2 polarization. Natural killer (NK) cells give rise to a complex NK/dendritic cell (DC) cross-talk that would help T(H)1 responses. OBJECTIVE: By analyzing peripheral blood NK cells from 12 patients with either allergic rhinitis or rhinitis and intermittent asthma, we evaluated whether these cells were impaired in their ability to interact with DCs. METHODS: Different circulating NK cell subsets were analyzed by flow cytofluorimetry. Mixed NK/DC cultures were performed to assess the reciprocal functional interactions. NK cells were analyzed for their ability to induce DC maturation and cytokine production, and to kill immature DCs. In addition, DCs were assessed for their ability to induce cytokine production by NK cells. RESULTS: We first analyzed the CD56++CD16+/- cells, a subset of circulating NK cells that is able to respond to DCs by proliferating and producing IFN-gamma. Our analysis revealed that this NK cell subpopulation was significantly reduced in most patients. This was reflected by reduced NK cell-mediated IFN-gamma production in response to DCs. Also, the capability of promoting DC maturation and/or killing immature DCs, a function sustained by CD56+CD16+ NK cells, was reduced in most patients. CONCLUSIONS: We suggest that allergic diseases are accompanied by a partial impairment of the NK cell capability of promoting and maintaining appropriate T(H)1 responses.

Perturbations of natural killer cell regulatory functions in respiratory allergic diseases. Publishing Authors By Initials

F Scordamaglia,M Balsamo,A Scordamaglia,A Moretta,MC Mingari,GW Canonica,L Moretta,M Vitale,

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Perturbations of natural killer cell regulatory functions in respiratory allergic diseases. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of allergy and clinical immunology

VOLUME: 121

Page Numbers: 479-85

Journal Abbreviation: J. Allergy Clin. Immunol.

ISSN: 1097-6825

DAY: 3

MONTH: 12

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 1275002

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AFFILIATION: Clinica Malattie dell'Apparato Respiratorio e Allergologia, Dipartimento di Medicina Interna, Università di Genova, Genoa, Italy.

Country: United States

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MEDLINETA: J Allergy Clin Immunol

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