Perturbation and differential Monte Carlo methods for measurement of optical properties in a layered epithelial tissue model.

Perturbation and differential Monte Carlo methods for measurement of optical properties in a layered epithelial tissue model. Research Abstract Details 

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Perturbation and differential Monte Carlo methods for measurement of optical properties in a layered epithelial tissue model. Abstract Text:

InSeok Seo,Joon S You,Carole K Hayakawa,Vasan Venugopalan,

The use of perturbation and differential Monte Carlo (pMC/dMC) methods in conjunction with nonlinear optimization algorithms were proposed recently as a means to solve inverse photon migration problems in regionwise heterogeneous turbid media. We demonstrate the application of pMC/dMC methods for the recovery of optical properties in a two-layer extended epithelial tissue model from experimental measurements of spatially resolved diffuse reflectance. The results demonstrate that pMC/dMC methods provide a rapid and accurate approach to solve two-region inverse photon migration problems in the transport regime, that is, on spatial scales smaller than a transport mean free path and in media where optical scattering need not dominate absorption. The pMC/dMC approach is found to be effective over a broad range of absorption (50 to 400%) and scattering (70 to 130%) perturbations. The recovery of optical properties from spatially resolved diffuse reflectance measurements is examined for different sets of source-detector separation. These results provide some guidance for the design of compact fiber-based probes to determine and isolate optical properties from both epithelial and stromal layers of superficial tissues.

Perturbation and differential Monte Carlo methods for measurement of optical properties in a layered epithelial tissue model. Publishing Authors By Initials

I Seo,JS You,CK Hayakawa,V Venugopalan,

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Perturbation and differential Monte Carlo methods for measurement of optical properties in a layered epithelial tissue model. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of biomedical optics

VOLUME: 12

Page Numbers: 014030

Journal Abbreviation:

ISSN: 1083-3668

DAY: 3

MONTH: 12

YEAR: 2007

Perturbation and differential Monte Carlo methods for measurement of optical properties in a layered epithelial tissue model. Information

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LANGUAGE: eng

NlmUniqueID: 9605853

Perturbation and differential Monte Carlo methods for measurement of optical properties in a layered epithelial tissue model. Keywords Mesh Terms:

KEYWORDS: Sensitivity and Specificity

MESH TERMS: methods

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Grant and Affiliation Information for Perturbation and differential Monte Carlo methods for measurement of optical properties in a layered epithelial tissue model.

AFFILIATION: University of California, Irvine, Department of Chemical Engineering and Materials Science, Irvine, California 92697, USA.

Country: United States

AGENCY: United States NIBIB

GRANT: R01-EB-00345

ACRONYM: EB

MEDLINETA: J Biomed Opt

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