Perspectives on genetic animal models of serotonin toxicity.

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Perspectives on genetic animal models of serotonin toxicity. Abstract Text:

Allan V Kalueff,Justin L Laporte,Dennis L Murphy,

Serotonin syndrome, or serotonin toxicity, is a serious disorder attributable to exaggerated serotonergic function in the brain, most commonly after antidepressant overdose or after combining several psychotropic medications. Similar condition (serotonin syndrome-like behavior) can be evoked in animals experimentally, following administration of serotonergic drugs. In addition to pharmacological stimulation, some genetic and other factors may contribute to serotonin toxicity, prompting the need for new experimental genetic models relevant to this disorder. Here we discuss current problems and perspectives regarding genetic animal models of serotonin-related syndromes, and outline the potential utility of these models in experimental neurochemistry and clinical research.

Perspectives on genetic animal models of serotonin toxicity. Publishing Authors By Initials

AV Kalueff,JL Laporte,DL Murphy,

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PUBMED ID PMID:

MEDLINE DATE: 2008 Mar-Apr

Perspectives on genetic animal models of serotonin toxicity. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Neurochemistry international

VOLUME: 52

Page Numbers: 649-58

Journal Abbreviation: Neurochem. Int.

ISSN: 0197-0186

DAY: 1

MONTH: 09

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 8006959

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AFFILIATION: Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, MD, USA.

Country: England

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MEDLINETA: Neurochem Int

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