Personality and gender differences in effects of d-amphetamine on risk taking.

Personality and gender differences in effects of d-amphetamine on risk taking. Research Abstract Details 

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Personality and gender differences in effects of d-amphetamine on risk taking. Abstract Text:

Tara L White,C W Lejuez,Harriet de Wit,Tara L White,C W Lejuez,Harriet de Wit,Tara L White,C W Lejuez,Harriet de Wit,

The effects of stimulant drugs on risk-taking behavior vary across individuals, even in healthy samples. These differences could relate to personality, which may share common mechanisms with drug effects or impulsive, risk-taking behavior. The current study investigated the role of temperament and gender in the effects of amphetamine on risk taking. Forty healthy men and women, aged 18 to 35, completed the Balloon Analogue Risk Task (BART; Lejuez et al., 2002) with three reward values after ingesting placebo or d-amphetamine (10, 20 mg). They completed the Multidimensional Personality Questionnaire Brief Form (MPQ-BF; Patrick et al., 2002), with three main scales: Trait reward sensitivity (Agentic Positive Emotionality; AgPEM), impulsivity (Constraint; CON), and negative affect (Negative Emotionality; NEM). d-Amphetamine (20 mg) decreased risk behavior in low AgPEM males, but increased risk behavior in high AgPEM males, producing positive correlations with AgPEM in men (r>/=+.55, p<.05). The drug did not affect risk-taking in women. There was evidence of discriminant validity between the AgPEM, NEM, and CON dimensions and behavioral responses to amphetamine. Implications for treatment and addiction are discussed. (PsycINFO Database Record (c) 2008 APA, all rights reserved).

Personality and gender differences in effects of d-amphetamine on risk taking. Publishing Authors By Initials

TL White,CW Lejuez,H de Wit,TL White,CW Lejuez,H de Wit,TL White,CW Lejuez,H de Wit,

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Personality and gender differences in effects of d-amphetamine on risk taking. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Experimental and clinical psychopharmacology

VOLUME: 15

Page Numbers: 599-609

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ISSN: 1064-1297

DAY: 8

MONTH: Dec

YEAR: 2007

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LANGUAGE: eng

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AFFILIATION: Center for Alcohol and Addiction Studies, Brown University.

Country: United States

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MEDLINETA: Exp Clin Psychopharmacol

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