Persistent human papillomavirus infection is associated with a generalized decrease in immune responsiveness in older women.

Persistent human papillomavirus infection is associated with a generalized decrease in immune responsiveness in older women. Research Abstract Details 

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Persistent human papillomavirus infection is associated with a generalized decrease in immune responsiveness in older women. Abstract Text:

Alfonso J ,Allan Hildesheim,Rolando Herrero,Matthew Trivett,Marcus Williams,Ivannia Atmetlla,Margarita ,Maricela Villegas,Mark Schiffman,Ana Cecilia ,Robert D Burk,Mariana Hildesheim,Enrique Freer, Bonilla, Bratti,Jay A Berzofsky,Ligia A Pinto,

The development of cervical cancer and its precursors are linked to persistent infection with oncogenic types of human papillomavirus (HPV). Host immune responses seem to be determinants of risk for this disease. However, little is known about the immunologic determinants of HPV persistence. Here, we examined the association between lymphoproliferative responses to antigens/mitogens and persistent HPV infection in women older than 45 years. Women included in this study were participants in a 10,000-woman population-based cohort study of cervical neoplasia in Costa Rica. Women older than 45 years and HPV DNA positive at a screening visit were selected as cases (n = 283). We selected a comparably sized control group of HPV DNA-negative women, matched to cases on age and time since enrollment (n = 261). At an additional clinical visit, women were cytologically and virologically rescreened, and cervical and blood specimens were collected. Proliferative responses to phytohemagglutinin (PHA), influenza virus (Flu), and HPV16 virus-like particle (VLP) were lower among women with persistent HPV infection [median counts per minute (cpm): 72,849 for PHA, 1,241 for Flu, and 727 for VLP] than for the control group (median cpm: 107,049 for PHA, 2,111 for Flu, and 2,068 for VLP). The decreases were most profound in women with long-term persistence and were only observed for the oldest age group (>/=65 years). Our results indicate that an impairment in host immunologic responses is associated to persistent HPV infection. The fact that effects were evident for all studied stimuli is suggestive of a generalized effect.

Persistent human papillomavirus infection is associated with a generalized decrease in immune responsiveness in older women. Publishing Authors By Initials

AJ ,A Hildesheim,R Herrero,M Trivett,M Williams,I Atmetlla,M ,M Villegas,M Schiffman,AC ,RD Burk,M Hildesheim,E Freer,J Bonilla,C Bratti,JA Berzofsky,LA Pinto,

For similar behavior and behavior mechanisms: behavior: sexual behavior research abstracts see: behavior and behavior mechanisms: behavior: sexual behavior research

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Persistent human papillomavirus infection is associated with a generalized decrease in immune responsiveness in older women. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Cancer research

VOLUME: 66

Page Numbers: 11070-6

Journal Abbreviation: Cancer Res.

ISSN: 0008-5472

DAY: 15

MONTH: Nov

YEAR: 2006

Persistent human papillomavirus infection is associated with a generalized decrease in immune responsiveness in older women. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2984705

Persistent human papillomavirus infection is associated with a generalized decrease in immune responsiveness in older women. Keywords Mesh Terms:

KEYWORDS: Sexual Behavior

MESH TERMS: immunology

Chemical & Substance for Abstract: Persistent human papillomavirus infection is associated with a generalized decrease in immune responsiveness in older women. Information

Substance Name: DNA, Viral

Registry Number: 0

Grant and Affiliation Information for Persistent human papillomavirus infection is associated with a generalized decrease in immune responsiveness in older women.

AFFILIATION: HPV Immunology Laboratory, Science Applications International Corporation-Frederick, Inc./National Cancer Institute-Frederick, Frederick, Maryland, USA.

Country: United States

AGENCY: United States NCI

GRANT: U01-CA78527

ACRONYM: CA

MEDLINETA: Cancer Res

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