Persistent depots of influenza antigen fail to induce a cytotoxic CD8 T cell response.

Persistent depots of influenza antigen fail to induce a cytotoxic CD8 T cell response. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Persistent depots of influenza antigen fail to induce a cytotoxic CD8 T cell response. Abstract Text:

Dawn M Jelley-Gibbs,John P Dibble,Deborah M Brown,Tara M Strutt,K Kai McKinstry,Susan L Swain,

Encounter with Ag during chronic infections results in the generation of phenotypically and functionally heterogeneous subsets of Ag-specific CD8 T cells. Influenza, an acute infection, results in the generation of similar CD8 T cell heterogeneity, which may be attributed to long-lived depots of flu Ags that stimulate T cell proliferation well after virus clearance. We hypothesized that the heterogeneity of flu-specific CD8 T cells and maintenance of T cell memory required the recruitment of new CD8 T cells to persistent depots of flu Ag, as was the case for flu-specific CD4 T cell responses. However, robust expansion and generation of highly differentiated cytolytic effectors and memory T cells only occurred when naive CD8 T cells were primed during the first week of flu infection. Priming of new naive CD8 T cells after the first week of infection resulted in low numbers of poorly functional effectors, with little to no cytolytic activity, and a negligible contribution to the memory pool. Therefore, although the presentation of flu Ag during the late stages of infection may provide a mechanism for maintaining an activated population of CD8 T cells in the lung, few latecomer CD8 T cells are recruited into the functional memory T cell pool.

Persistent depots of influenza antigen fail to induce a cytotoxic CD8 T cell response. Publishing Authors By Initials

DM Jelley-Gibbs,JP Dibble,DM Brown,TM Strutt,KK McKinstry,SL Swain,

For similar cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes: cd8-positive t-lymphocytes: t-lymphocytes, cytotoxic research abstracts see: cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes: cd8-positive t-lymphocytes: t-lymphocytes, cytotoxic research

PUBMED ID PMID:

MEDLINE DATE:

Persistent depots of influenza antigen fail to induce a cytotoxic CD8 T cell response. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 178

Page Numbers: 7563-70

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 15

MONTH: Jun

YEAR: 2007

Persistent depots of influenza antigen fail to induce a cytotoxic CD8 T cell response. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985117

Persistent depots of influenza antigen fail to induce a cytotoxic CD8 T cell response. Keywords Mesh Terms:

KEYWORDS: T-Lymphocytes, Cytotoxic

MESH TERMS: immunology

Chemical & Substance for Abstract: Persistent depots of influenza antigen fail to induce a cytotoxic CD8 T cell response. Information

Substance Name: Receptors, Antigen, T-Cell

Registry Number: 0

Grant and Affiliation Information for Persistent depots of influenza antigen fail to induce a cytotoxic CD8 T cell response.

AFFILIATION: Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA. djgibbs@trudeauinstitute.org

Country: United States

AGENCY: United States NIAID

GRANT: U54 AI 057158

ACRONYM: AI

MEDLINETA: J Immunol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Persistent depots of influenza antigen fail to induce a cytotoxic CD8 T cell response Related Publications

• A phase II clinical trial of ZD1839 (Iressa) in combination with docetaxel as first-line treatment in patients with advanced breast cancer.
• A synthesis of dl-dethiobiotin and some related compounds.
• Characterisation of enamel white spot lesions using X-ray micro-tomography.
• Characterization of nanoindentation-induced residual stresses in human enamel by Raman microspectroscopy.
• Comparative assessment of hardening of demineralized dentin under lining materials using an ultramicroindentation system.
• Determination of endogenous norepinephrine levels in different chambers of the rat heart by capillary electrophoresis coupled with amperometric detection.
• Diamond microelectrodes for in vitro electroanalytical measurements: current status and remaining challenges.
• Differences in sympathetic neuroeffector transmission to rat mesenteric arteries and veins as probed by in vitro continuous amperometry and video imaging.
• Effect of Training Volume on HDL-Cholesterol: A 6-year Case Study: 949: June 2 10:15 AM - 10:30 AM.
• Environmental and intrinsic factors lead to antigen unresponsiveness in CD4(+) recent thymic emigrants from aged mice.
• Facile: a command-line network compiler for systems biology.
• Functional significance of strain distribution in the human mandible under masticatory load: numerical predictions.
• High mucosal serotonin availability in neonatal guinea pig ileum is associated with low serotonin transporter expression.
• In vitro continuous amperometric monitoring of 5-hydroxytryptamine release from enterochromaffin cells of the guinea pig ileum.
• In vitro continuous amperometry with a diamond microelectrode coupled with video microscopy for simultaneously monitoring endogenous norepinephrine and its effect on the contractile response of a rat mesenteric artery.
• Influence of garlic (Allium sativum) on the pharmacokinetics of docetaxel.
• Influenza in Scotland in the early months of 1949.
• Kinetics of hydrolysis and displacement reactions of beta, beta1-dichlorodiethyl sulfide and of beta-chloro-beta1-hydroxydiethyl sulfide.
• On the design of dental resin-based composites: A micromechanical approach.
• Open access and medicinal chemistry.
• Optically transparent diamond electrode for use in ir transmission spectroelectrochemical measurements.
• Persistent depots of influenza antigen fail to induce a cytotoxic CD8 T cell response.
• Personal-protection measures against mosquitoes: a study of practices and costs in a district, in the Indian state of Orissa, where malaria and lymphatic filariasis are co-endemic.
• Rapid default transition of CD4 T cell effectors to functional memory cells.
• Restoration of non-carious cervical lesions Part II. Restorative material selection to minimise fracture.
• SAP is required for Th cell function and for immunity to influenza.
• Simultaneous surveys of food consumption in various camps in the United States Army.
• The laboratory investigation of virus diseases.
• Ultrastructure of dentine carious lesions.
• Unique ability of activated CD4+ T cells but not rested effectors to migrate to non-lymphoid sites in the absence of inflammation.