Persistent changes in interleukin-6 and lower extremity function following hip fracture.

Persistent changes in interleukin-6 and lower extremity function following hip fracture. Research Abstract Details 

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Persistent changes in interleukin-6 and lower extremity function following hip fracture. Abstract Text:

Ram R Miller,Anne R Cappola,Michelle D Shardell,William G Hawkes,Janet A Yu-Yahiro,J Richard Hebel,Jay Magaziner,

BACKGROUND: A hip fracture often heralds a period of functional decline in elderly persons. Although an inflammatory reaction would be expected following a hip fracture, whether the degree of this response is associated with adverse functional outcomes is unknown. METHODS: In a cohort from the Baltimore Hip Studies, women aged 65 years or older with a hip fracture were evaluated at 3 or 10 days (baseline) and 2, 6, and 12 months (follow-up) postfracture. Serum was analyzed for interleukin-6 (IL-6) level. A score of timed performance of 9 tasks, the Lower Extremity Gain Scale (LEGS) was calculated at each evaluation. We divided participants into tertiles based on their cytokine levels at 2, 6, and 12 months, and examined the LEGS score trajectories as a function of IL-6 tertile using generalized estimating equations, adjusting for age, prefracture function, body fat, pain, cognitive function, type of surgical repair, the number of in-hospital complications, and the number of comorbid medical conditions. RESULTS: At baseline, 2, 6, and 12 months, respectively, 149, 95, 101, and 82 participants provided serum samples; of these participants 65, 78, and 59 also provided a LEGS measure at 2, 6, and 12 months, respectively. At 12 months postfracture the median (interquartile range) of serum IL-6 levels was 7.4 (4.0, 15.9) pg/mL. Participants in the lowest tertile of IL-6 level performed better on the LEGS than did those in the highest tertile (p =.008). At 12 months postfracture, participants in the lowest tertile scored 5.3 points better (95% confidence interval, 2.0-8.6) on the LEGS than did those in the highest tertile (p =.002). CONCLUSIONS: Higher IL-6 levels are adversely associated with recovery of lower extremity function after hip fracture. Factors that predict cytokine response and the potential mechanisms by which this effect is mediated warrant further study.

Persistent changes in interleukin-6 and lower extremity function following hip fracture. Publishing Authors By Initials

RR Miller,AR Cappola,MD Shardell,WG Hawkes,JA Yu-Yahiro,JR Hebel,J Magaziner,

For similar body regions: extremities: lower extremity research abstracts see: body regions: extremities: lower extremity research

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Persistent changes in interleukin-6 and lower extremity function following hip fracture. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The journals of gerontology. Series A, Biological

VOLUME: 61

Page Numbers: 1053-8

Journal Abbreviation: J. Gerontol. A Biol. Sci. Med.

ISSN: 1079-5006

DAY: 3

MONTH: Oct

YEAR: 2006

Persistent changes in interleukin-6 and lower extremity function following hip fracture. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9502837

Persistent changes in interleukin-6 and lower extremity function following hip fracture. Keywords Mesh Terms:

KEYWORDS: Lower Extremity

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Persistent changes in interleukin-6 and lower extremity function following hip fracture. Information

Substance Name: Interleukin-6

Registry Number: 0

Grant and Affiliation Information for Persistent changes in interleukin-6 and lower extremity function following hip fracture.

AFFILIATION: University of Maryland, School of Medicine, Division of Gerontology, Department of Epidemiology and Preventive Medicine, 660 W. Redwood St., Suite 200, Baltimore, MD 21201, USA. rrmiller@epi.umaryland.edu

Country: United States

AGENCY: United States NIA

GRANT: R37 AG09901

ACRONYM: AG

MEDLINETA: J Gerontol A Biol Sci Med Sci

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