Persistent akinetic-rigid side effects of neuroleptics may indicate Wilson's disease.

Persistent akinetic-rigid side effects of neuroleptics may indicate Wilson's disease. Research Abstract Details 

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Persistent akinetic-rigid side effects of neuroleptics may indicate Wilson's disease. Abstract Text:

Zsuzsanna Aschermann,Ferenc Szalay, Schmidt, Komoly,Zsolt ,Zsuzsanna Aschermann,Ferenc Szalay, Schmidt, Komoly,Zsolt ,

Here we report two cases, where neuroleptic treatment provoked persistent akinetic-rigid symptoms resulting in the diagnosis of Wilson's disease. No liver function abnormalities suggested Wilson's disease in one of the cases. In both cases, the akinetic-rigid symptoms were originally attributed to side effects of neuroleptics, but symptoms persisted after discontinuation of treatment. In one of the cases, T2-weighted cranial MRI indicated bilateral hyperintense signals in the basal ganglia. Our cases suggest that in a subgroup of Wilson's disease, dopamine receptor antagonists may provoke akinetic-rigid neurological symptoms possibly due to the damage of dopaminergic neurons. Persistent akinetic-rigid side effects of neuroleptics in young patients thus require diagnostic tests to exclude Wilson's disease even in unsuspected cases.

Persistent akinetic-rigid side effects of neuroleptics may indicate Wilson's disease. Publishing Authors By Initials

Z Aschermann,F Szalay,E Schmidt,S Komoly,Z ,Z Aschermann,F Szalay,E Schmidt,S Komoly,Z ,

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Persistent akinetic-rigid side effects of neuroleptics may indicate Wilson's disease. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Ideggyógyászati szemle

VOLUME: 60

Page Numbers: 404-5

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ISSN: 0019-1442

DAY: 30

MONTH: Sep

YEAR: 2007

Persistent akinetic-rigid side effects of neuroleptics may indicate Wilson's disease. Information

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LANGUAGE: eng

NlmUniqueID: 17510500

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Grant and Affiliation Information for Persistent akinetic-rigid side effects of neuroleptics may indicate Wilson's disease.

AFFILIATION: Department of Neurology, University of Pécs, Pécs.

Country: Hungary

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MEDLINETA: Ideggyogy Sz

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