Persistence of restricted CD4 T cell expansions in SIV-infected macaques resistant to SHIV89.6P superinfection.

Persistence of restricted CD4 T cell expansions in SIV-infected macaques resistant to SHIV89.6P superinfection. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Persistence of restricted CD4 T cell expansions in SIV-infected macaques resistant to SHIV89.6P superinfection. Abstract Text:

Attempts to evaluate the protective effect of live attenuated SIV vaccine strains have yielded variable results depending on the route of immunization, the level of attenuation, the level of divergence between the vaccine candidate and the challenge. The protective mechanisms induced by these vaccines are still not well understood. In an effort to address whether the diversity of the CD4+ T cell repertoire in cynomolgus macaques plays a role in the immunological protection following SIVmacC8 infection, we have performed a longitudinal follow-up of the CD4 repertoire by heteroduplex tracking assay in macaques mock-infected or infected with either the attenuated SIVmacC8 or its homologous SIVmacJ5 and challenged with simian-human immunodeficiency virus (SHIV89.6P). Viral load and CD4 absolute counts were determined in these animals and the presence of SHIV89.6P virus in challenged animals was evaluated by PCR and serology. In all macaques that were protected against the challenging virus, we demonstrated a reduced diversity in the CD4+ TRBV repertoire and a few dominant CD4+ T cell clones during early primary infection. In contrast, CD4 TRBV repertoire in unprotected macaques remained highly diverse. Moreover, some of the CD4 T cell clones that were expanded during primary SIV infection re-emerged after challenge suggesting their role in protection against the challenging virus. These results underline the importance of maintaining the CD4 T cell repertoire developed during acute infection and point to the restriction of the CD4 response to the vaccine as a correlate of protection.

Persistence of restricted CD4 T cell expansions in SIV-infected macaques resistant to SHIV89.6P superinfection. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Persistence of restricted CD4 T cell expansions in SIV-infected macaques resistant to SHIV89.6P superinfection. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Virology

VOLUME: 377

Page Numbers: 239-47

Journal Abbreviation: Virology

ISSN: 0042-6822

DAY: 1

MONTH: Aug

YEAR: 2008

Persistence of restricted CD4 T cell expansions in SIV-infected macaques resistant to SHIV89.6P superinfection. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 110674

Persistence of restricted CD4 T cell expansions in SIV-infected macaques resistant to SHIV89.6P superinfection. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Persistence of restricted CD4 T cell expansions in SIV-infected macaques resistant to SHIV89.6P superinfection. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Persistence of restricted CD4 T cell expansions in SIV-infected macaques resistant to SHIV89.6P superinfection.

AFFILIATION: Department of Microbiology and Immunology, McGill University, Montreal, Canada PQ H3A 2B4; Centre de Recherche du Centre Hospitalier de l'Université de Montreal (CHUM), Montreal, Canada PQ H2W 1T8.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Virology

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Persistence of restricted CD4 T cell expansions in SIV-infected macaques resistant to SHIV896P superinfection Related Publications

• Drug abuse and environment in youth. A study of a junior high school population in a county of Akershus, Norway.
• Local anesthetics. An electrophysiological investigation of local anesthesia of peripheral nerves, with special reference to xylocaine.
• Measurement of leakage of tuberculin syringes.
• Persistence of restricted CD4 T cell expansions in SIV-infected macaques resistant to SHIV89.6P superinfection.
• The function of the urethral blood flow in maintaining urinary continence. A preliminary report.
• [A rehabilitation department for psychiatric patients. Integration of milieu therapy and occupational therapy]
• [Day treatment of psychiatric patients. Experiences with day patients in a psychiatric clinic]
• [Drug and alcohol education among secondary school pupils. An evaluation study in Akershus]
• [Female stress incontinence]
• [Mixed abuse of drugs by adolescents]
• [Occupational disability in adults. Various statistical information with comments]
• [Prevention of drug abuse among adolescents]
• [Rehabilitation of psychoses]
• [Simultaneous urethrocystometry. A new aid in the study of urinary incontinence in women]
• [Technique for removal of lower impacted wisdom teeth]
• [Tumoral counterindications against resection of rectum carcinoma.]
• [Use of drugs, environment and life style in adolescents]