Peroxisome proliferator-activated receptors: new players in the field of reproduction.

Peroxisome proliferator-activated receptors: new players in the field of reproduction. Research Abstract Details 

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Peroxisome proliferator-activated receptors: new players in the field of reproduction. Abstract Text:

Bettina Toth,Daniela Hornung,Christoph Scholz,Schima Djalali,Klaus Friese,Udo Jeschke,Bettina Toth,Daniela Hornung,Christoph Scholz,Schima Djalali,Klaus Friese,Udo Jeschke,

Peroxisome proliferator-activated receptors (PPAR) are members of the nuclear hormone receptor superfamily. Synthetic ligands to one family member, PPARgamma, are currently widely used as treatment for chronic diseases such as diabetes type II and other insulin resistances, e.g. as seen in polycystic ovary syndrome (PCOS). Moreover, novel approaches employing knock-out mice demonstrated that PPARgamma seems to play a key role in placental and fetal development. This review describes recent insights into the role of PPARs in human reproduction with specific reference to infertility, placental maturation and fetal development as well as disturbed pregnancy. Further, we highlight the current knowledge on synthetic ligands to PPARgamma used as a treatment in women with PCOS.

Peroxisome proliferator-activated receptors: new players in the field of reproduction. Publishing Authors By Initials

B Toth,D Hornung,C Scholz,S Djalali,K Friese,U Jeschke,B Toth,D Hornung,C Scholz,S Djalali,K Friese,U Jeschke,

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Peroxisome proliferator-activated receptors: new players in the field of reproduction. Journal Published:

PUBLICATION TYPE: Review

Journal: American journal of reproductive immunology (New Y

VOLUME: 58

Page Numbers: 289-310

Journal Abbreviation: Am. J. Reprod. Immunol.

ISSN: 1046-7408

DAY: 7

MONTH: Sep

YEAR: 2007

Peroxisome proliferator-activated receptors: new players in the field of reproduction. Information

Number of References: 173

LANGUAGE: eng

NlmUniqueID: 8912860

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Grant and Affiliation Information for Peroxisome proliferator-activated receptors: new players in the field of reproduction.

AFFILIATION: Department of Obstetrics and Gynecology, Ludwig-Maximilians-University, Grosshadern, Munich, Germany. bettina.toth@med.uni-muenchen.de

Country: Denmark

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MEDLINETA: Am J Reprod Immunol

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