Peroxisome Proliferator-Activated Receptor-{gamma} Gene: A Key Regulator of Adipocyte Differentiation in Chickens.

Peroxisome Proliferator-Activated Receptor-{gamma} Gene: A Key Regulator of Adipocyte Differentiation in Chickens. Research Abstract Details 

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Peroxisome Proliferator-Activated Receptor-{gamma} Gene: A Key Regulator of Adipocyte Differentiation in Chickens. Abstract Text:

Y Wang,Y Mu,H Li,N Ding,Q Wang,Y Wang,S Wang,N Wang,Y Wang,Y Mu,H Li,N Ding,Q Wang,Y Wang,S Wang,N Wang,

The peroxisome proliferator-activated receptors (PPAR) are members of the nuclear hormone receptor superfamily. Peroxisome proliferator-activated receptor-gamma is regarded as a "master regulator" of adipocyte differentiation in mammals. The current study was designed to investigate the function and regulatory mechanism of PPARgamma in chicken adipogenesis by RNA interference. Preadipocytes were isolated from the abdominal fat tissue of 12-d-old chickens and cultured. Small-interference PPARgamma RNA (siPPARgamma) was synthesized by in vitro transcription and transfected into chicken preadipocytes by using liposomes. The suppressive effect of siPPARgamma was detected by real-time reverse-transcription PCR and reverse-transcription PCR. The results showed that transient transfection with siPPARgamma significantly inhibited differentiation and enhanced proliferation of chicken preadipocytes (P < 0.05). The adipogenesis-associated adipocyte fatty acid-binding protein gene was down-regulated when PPARgamma was silenced. The current work indicates that PPARgamma is a key regulator of chicken preadipocyte differentiation.

Peroxisome Proliferator-Activated Receptor-{gamma} Gene: A Key Regulator of Adipocyte Differentiation in Chickens. Publishing Authors By Initials

Y Wang,Y Mu,H Li,N Ding,Q Wang,Y Wang,S Wang,N Wang,Y Wang,Y Mu,H Li,N Ding,Q Wang,Y Wang,S Wang,N Wang,

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Peroxisome Proliferator-Activated Receptor-{gamma} Gene: A Key Regulator of Adipocyte Differentiation in Chickens. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Poultry science

VOLUME: 87

Page Numbers: 226-32

Journal Abbreviation: Poult. Sci.

ISSN: 0032-5791

DAY: 23

MONTH: Feb

YEAR: 2008

Peroxisome Proliferator-Activated Receptor-{gamma} Gene: A Key Regulator of Adipocyte Differentiation in Chickens. Information

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LANGUAGE: eng

NlmUniqueID: 401150

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Grant and Affiliation Information for Peroxisome Proliferator-Activated Receptor-{gamma} Gene: A Key Regulator of Adipocyte Differentiation in Chickens.

AFFILIATION: College of Animal Science and Technology, Northeast Agricultural University, Harbin, 150030, P. R. China.

Country: United States

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MEDLINETA: Poult Sci

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