Peroxisome proliferator-activated receptor-gamma agonists suppress the production of IL-12 family cytokines by activated glia.

Peroxisome proliferator-activated receptor-gamma agonists suppress the production of IL-12 family cytokines by activated glia. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Peroxisome proliferator-activated receptor-gamma agonists suppress the production of IL-12 family cytokines by activated glia. Abstract Text:

Jihong Xu,Paul D Drew,

The IL-12 family of cytokines, which include IL-12, IL-23, and IL-27, play critical roles in the differentiation of Th1 cells and are believed to contribute to the development of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), an animal model of MS. Relatively little is known concerning the expression of IL-12 family cytokines by cells of the CNS, the affected tissue in MS. Previously, we and others demonstrated that peroxisome proliferator-activated receptor (PPAR)-gamma agonists suppress the development of EAE, alter T cell proliferation and phenotype, and suppress the activation of APCs. The present studies demonstrated that PPAR-gamma agonists, including the naturally occurring 15-deoxy-Delta(12,14)-PGJ(2) and the synthetic thiazoladinedione rosiglitazone, inhibited the induction of IL-12p40, IL-12p70 (p35/p40), IL-23 (p19/p40), and IL-27p28 proteins by LPS-stimulated primary microglia. In primary astrocytes, LPS induced the production of IL-12p40, IL-23, and IL-27p28 proteins. However, IL-12p70 production was not detected in these cells. The 15-deoxy-Delta(12,14)-PGJ(2) potently suppressed IL-12p40, IL-23, and IL-27p28 production by primary astrocytes, whereas rosiglitazone suppressed IL-23 and IL-27p28, but not IL-12p40 in these cells. These novel observations suggest that PPAR-gamma agonists modulate the development of EAE, at least in part, by inhibiting the production of IL-12 family cytokines by CNS glia. In addition, we demonstrate that PPAR-gamma agonists inhibit TLR2, MyD88, and CD14 expression in glia, suggesting a possible mechanism by which these agonists modulate IL-12 family cytokine expression. Collectively, these studies suggest that PPAR-gamma agonists may be beneficial in the treatment of MS.

Peroxisome proliferator-activated receptor-gamma agonists suppress the production of IL-12 family cytokines by activated glia. Publishing Authors By Initials

J Xu,PD Drew,

For similar cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes research abstracts see: cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes research

PUBMED ID PMID:

MEDLINE DATE:

Peroxisome proliferator-activated receptor-gamma agonists suppress the production of IL-12 family cytokines by activated glia. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 178

Page Numbers: 1904-13

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 1

MONTH: Feb

YEAR: 2007

Peroxisome proliferator-activated receptor-gamma agonists suppress the production of IL-12 family cytokines by activated glia. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985117

Peroxisome proliferator-activated receptor-gamma agonists suppress the production of IL-12 family cytokines by activated glia. Keywords Mesh Terms:

KEYWORDS: T-Lymphocytes

MESH TERMS: drug effects

Chemical & Substance for Abstract: Peroxisome proliferator-activated receptor-gamma agonists suppress the production of IL-12 family cytokines by activated glia. Information

Substance Name: Interleukin-12

Registry Number: 187348-17-0

Grant and Affiliation Information for Peroxisome proliferator-activated receptor-gamma agonists suppress the production of IL-12 family cytokines by activated glia.

AFFILIATION: Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

Country: United States

AGENCY: United States NINDS

GRANT: NS42860

ACRONYM: NS

MEDLINETA: J Immunol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Peroxisome proliferator-activated receptor-gamma agonists suppress the production of IL-12 family cytokines by activated glia Related Publications

• ;Having cancer changed my life, and changed my life forever': survival, illness legacy and service provision following cancer in childhood.
• A design for a stress-breaker and its application.
• A point prevalence survey of wounds in north-east England.
• Acculturation stress and alcohol usage among Canadian Indians in Toronto.
• Antifungal serum concentration monitoring: an update.
• Atrial electrograms after cardiac surgery: survey of clinical practice.
• Commentaries on Lewis's 'The early alcoholism treatment movement in Australia, 1859-1939'.
• Cytomegalovirus retinitis: the neglected disease of the AIDS pandemic.
• Development of new cytomegalovirus UL97 and DNA polymerase mutations conferring drug resistance after valganciclovir therapy in allogeneic stem cell recipients.
• Distribution of NMDA receptor subunit NR1 in arctic ground squirrel central nervous system.
• Dynamic tracking of ischemia in the surface electrocardiogram.
• Effect of different dietary methionine sources on intestinal microbial populations in broiler chickens.
• Facts we don't want to face.
• Germination and growth of lettuce (Lactuca sativa) at low atmospheric pressure.
• In situ development of carpospores of Bonnemaisonia asparagoides.
• Karhunen-Loève representation distinguishes ST-T wave morphology differences in emergency department chest pain patients with non-ST-elevation myocardial infarction versus nonacute coronary syndrome.
• Methylation of TIMP3 in esophageal squamous cell carcinoma.
• Morals, science and chance.
• Osteonecrosis of the jaws and bisphosphonate therapy.
• Peroxisome proliferator-activated receptor-alpha agonist fenofibrate regulates IL-12 family cytokine expression in the CNS: relevance to multiple sclerosis.
• Peroxisome proliferator-activated receptor-gamma agonists suppress the production of IL-12 family cytokines by activated glia.
• Preventing torsades de pointes by careful cardiac monitoring in hospital settings.
• Profiling of mitochondrial associated proteins from rat colon.
• Protein therapy; the clinical use of a new protein preparation.
• Pulling it all together: case studies on ECG monitoring.
• Simultaneous determination of 33 amino acids and dipeptides in spent cell culture media by gas chromatography-flame ionization detection following liquid and solid phase extraction.
• Sterically controlled recognition of macromolecular sequence information by molecular tweezers.
• Subclassification of peripheral dopamine receptors.
• The effects of a COX-2 inhibitor meloxicam on squamous cell carcinoma of the esophagus in vivo.
• Treatment is an art to which science can contribute: the 2nd James Rankin Oration.